Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform

被引：22

作者：

Antonio Garcia-Leon, Juan ^{[1
,2
]}

Vitorica, Javier ^{[2
,3
,4
]}

Gutierrez, Antonia ^{[1
,2
]}

机构：

[1] Univ Malaga, Dept Biol Celular Genet & Fisiol, Fac Ciencias, Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain

[2] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid 28031, Spain

[3] Univ Seville, Fac Farm, Dept Bioquim & Biol Mol, E-41012 Seville, Spain

[4] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBiS, Seville 41013, Spain

来源：

FUTURE MEDICINAL CHEMISTRY | 2019年 / 11卷 / 11期

关键词：

Alzheimer's disease; amyotrophic lateral sclerosis; CRISPR-Cas9; disease modeling; drug screening; hiPSCs; human-induced pluripotent stem cells; Huntington's disease; multiple sclerosis; neurodegenerative disease; Parkinson's disease; MICROGLIA-LIKE CELLS; OLIGODENDROCYTE PROGENITOR CELLS; FAMILIAL ALZHEIMERS-DISEASE; DOUBLE-STRAND BREAKS; IN-VITRO; EFFICIENT GENERATION; CEREBRAL ORGANOIDS; MOTOR-NEURONS; MOUSE MODEL; DIFFERENTIATION;

D O I：

10.4155/fmc-2018-0520

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies counteracting the disease progression. The advent of human pluripotent stem cells has revolutionized the field allowing the generation of disease-relevant neural cell types that can be used for disease modeling, drug screening and, possibly, cell transplantation purposes. In this Review, we discuss the applications of human pluripotent stem cells, the development of efficient protocols for the derivation of the different neural cells and their applicability for robust in vitro disease modeling and drug screening platforms for most common neurodegenerative conditions.

引用

页码：1305 / 1322

页数：18

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