Decursin inhibits tumor growth, migration, and invasion in gastric cancer by down-regulating CXCR7 expression

被引：1

作者：

Kim, Solbi ^{[1
,2
]}

Kim, Ji-Eun ^{[4
]}

Kim, Nayoung ^{[1
,2
]}

Joo, Mina ^{[1
,2
]}

Lee, Myung-Won ^{[3
]}

Jeon, HeungJin ^{[1
,5
]}

Ryu, Hyewon ^{[3
]}

Song, Ik-Chan ^{[3
]}

Song, Gyu-Yong ^{[1
,4
]}

Lee, Hyo Jin ^{[1
,3
,5
]}

机构：

[1] Chungnam Natl Univ, Coll Med, Infect Control Convergence Res Ctr, Daejeon, South Korea

[2] Chungnam Natl Univ, Coll Med, Dept Med Sci, Daejeon, South Korea

[3] Chungnam Natl Univ, Coll Med, Dept Internal Med, 282 Munhwa Ro, Daejeon 35015, South Korea

[4] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea

[5] Chungnam Natl Univ, Canc Res Inst, Daejeon, South Korea

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2019年 / 9卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

CXCR7; decursin; growth; migration; invasiveness; gastric cancer; CHEMOKINE RECEPTOR CXCR7; CELL-PROLIFERATION; BREAST; INFLAMMATION; SUPPRESSES; ACTIVATION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CXC chemokine receptor 7 (CXCR7) is highly expressed in various type of cancers and promotes cancer progression and metastasis. However, the biological role and regulation of CXCR7 in gastric cancer remains unclear, and little is known about compounds that modulate CXCR7. Here, we investigated the role of CXCR7 in gastric tumorigenesis, and the effects of decursin, which is derived from Angelica gigas Nakai, on CXCR7. Our results showed that CXCR7 significantly promoted growth of gastric cancer cells and increased migration and invasion, which was mediated by the STAT3/c-Myc pathway. We also confirmed that decursin had an antitumor effect through down-regulating the expression of CXCR7 in gastric cancer. Furthermore, apoptotic cell death was induced through the reduction of anti-apoptotic factors such as Bcl-2 in vitro and in vivo. Our findings show that CXCR7 in gastric cancer promotes cancer progression through the STAT3/c-Myc pathway and that decursin is a natural compound that may target CXCR7 in gastric cancer treatment.

引用

页码：2007 / +

页数：14

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