Thermosensitive Micelles Based on Folate-Conjugated Poly(N-vinylcaprolactam)-block-Poly(ethylene glycol) for Tumor-Targeted Drug Delivery

被引：75

作者：

Prabaharan, Mani ^{[2
]}

Grailer, Jamison J. ^{[3
]}

Steeber, Douglas A. ^{[3
]}

Gong, Shaoqin ^{[1
,2
]}

机构：

[1] Univ Wisconsin, Dept Mat, Milwaukee, WI 53211 USA

[2] Univ Wisconsin, Dept Mech Engn, Milwaukee, WI 53211 USA

[3] Univ Wisconsin, Dept Biol Sci, Milwaukee, WI 53211 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2009年 / 9卷 / 08期

基金：

美国国家科学基金会;

关键词：

core/shell polymers; drug delivery systems; micelles; synthesis; thermosensitive; WATER; IMMUNOTHERAPY; NANOPARTICLES; COPOLYMERS; POLYMERS; DESIGN;

D O I：

10.1002/mabi.200800366

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thermosensitive PNVCL-b-PEG block copolymer coupled with folic acid was prepared as an anti-cancer drug carrier. This polymer self-assembled into stable micelles in aqueous solutions at above 33 degrees C. At 37 degrees C, the release profile of PNVCL-b-PEG-FA micelles showed a slower andmore controlled release of the entrapped 5-FU than that at 25 degrees C. The blank and 5-FU-loaded PNVCL-b-PEG-FA micelles did not induce remarkable cytotoxicity against the EA.hy 926 human endothelial cell line; however, 5-FUloaded PNVCL-b-PEG-FA micelles showed a cytotoxicity effect against 4T1 mouse mammary carcinoma cells due to the availability of loaded anti-cancer drugs delivered to the inside of the cancer cells by the folate-receptor-mediated endocytosis process.

引用

页码：744 / 753

页数：10

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