Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient

被引：152

作者：

Andonov, Anton ^{[1
]}

Robbins, Mark ^{[2
]}

Borlang, Jamie ^{[1
]}

Cao, Jingxin ^{[1
]}

Hatchette, Todd ^{[3
,5
]}

Stueck, Ashley ^{[3
,5
]}

Deschambault, Yvon ^{[1
]}

Murnaghan, Kyle ^{[4
]}

Varga, Jessy ^{[1
]}

Johnston, Lynn ^{[4
]}

机构：

[1] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada

[2] Nova Scotia Hlth Author, Div Infect Dis, Halifax, NS, Canada

[3] Nova Scotia Hlth Author, Dept Pathol & Lab Med, Halifax, NS, Canada

[4] Nova Scotia Hlth Author, Dept Med, Halifax, NS, Canada

[5] Dalhousie Univ, Dept Pathol, Halifax, NS, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 220卷 / 06期

关键词：

hepatitis E virus; Hepeviridae; phylogenetic analysis; Western blot; immunocompetent; INFECTION; FAMILY;

D O I：

10.1093/infdis/jiz025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.

引用

页码：951 / 955

页数：5

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