Pediatric Hospitalizations Associated with 2009 Pandemic Influenza A (H1N1) in Argentina

被引：316

作者：

Libster, Romina ^{[2
]}

Bugna, Jimena ^{[2
]}

Coviello, Silvina ^{[2
]}

Hijano, Diego R. ^{[3
,4
]}

Dunaiewsky, Mariana ^{[4
,5
]}

Reynoso, Natalia ^{[4
,6
]}

Cavalieri, Maria L. ^{[4
,7
]}

Guglielmo, Maria C. ^{[4
,5
]}

Soledad Areso, M. ^{[4
,7
]}

Gilligan, Tomas ^{[8
]}

Santucho, Fernanda ^{[8
]}

Cabral, Graciela ^{[9
]}

Gregorio, Gabriela L. ^{[9
]}

Moreno, Rina ^{[9
]}

Lutz, Maria I. ^{[9
]}

Panigasi, Alicia L. ^{[9
]}

Saligari, Liliana ^{[8
,9
]}

Caballero, Mauricio T. ^{[4
,10
]}

Eguees Almeida, Rodrigo M. ^{[4
,10
]}

Gutierrez Meyer, Maria E. ^{[4
,10
]}

Neder, Maria D. ^{[5
]}

Davenport, Maria C. ^{[5
]}

Del Valle, Maria P. ^{[5
]}

Santidrian, Valeria S. ^{[5
]}

Mosca, Guillermina ^{[4
,6
]}

Garcia Dominguez, Mercedes ^{[6
]}

Alvarez, Liliana

Landa, Patricia ^{[8
]}

Pota, Ana ^{[8
]}

Bolonati, Norma ^{[8
]}

Dalamon, Ricardo ^{[8
]}

Sanchez Mercol, Victoria I. ^{[4
,7
]}

Espinoza, Marco ^{[2
]}

Carlos Peuchot, Juan ^{[7
]}

Karolinski, Ariel ^{[8
]}

Bruno, Miriam ^{[8
]}

Borsa, Ana ^{[10
]}

Ferrero, Fernando ^{[5
]}

Bonina, Angel ^{[5
]}

Ramonet, Margarita ^{[9
]}

Albano, Lidia C. ^{[9
]}

Luedicke, Nora ^{[6
]}

Alterman, Elias ^{[2
]}

Savy, Vilma ^{[11
]}

Baumeister, Elsa ^{[11
]}

Chappell, James D. ^{[12
]}

Edwards, Kathryn M.

Melendi, Guillermina A. ^{[2
]}

Polack, Fernando P. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Dept Pediat, Vanderbilt Vaccine Ctr, Nashville, TN 37232 USA

[2] Fdn INFANT, Buenos Aires, DF, Argentina

[3] Hosp Ninos Sor Ludovica La Plata, Inst Desarrollo & Invest Pediat, Buenos Aires, DF, Argentina

[4] Minist Ciencia Tecn & Innovac Prod, Programa INFANT, Buenos Aires, DF, Argentina

[5] Hosp Ninos Pedro de Elizalde, Buenos Aires, DF, Argentina

[6] Hosp Materno Infantil Dr Carlos Gianantonio, Buenos Aires, DF, Argentina

[7] Hosp Eva Peron, Buenos Aires, DF, Argentina

[8] Hosp Durand, Buenos Aires, DF, Argentina

[9] Hosp Posadas, Buenos Aires, DF, Argentina

[10] Hosp Ninos Sor Maria Ludovica, Buenos Aires, DF, Argentina

[11] Dr Carlos G Malbran Inst, Buenos Aires, DF, Argentina

[12] Vanderbilt Univ, Dept Pathol, Nashville, TN 37232 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 01期

关键词：

UNITED-STATES; CHILDREN; VIRUS; INFECTION; MORTALITY; ILLNESS; WAVE;

D O I：

10.1056/NEJMoa0907673

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND While the Northern Hemisphere experiences the effects of the 2009 pandemic influenza A (H1N1) virus, data from the recent influenza season in the Southern Hemisphere can provide important information on the burden of disease in children. METHODS We conducted a retrospective case series involving children with acute infection of the lower respiratory tract or fever in whom 2009 H1N1 influenza was diagnosed on reverse-transcriptase polymerase-chain-reaction assay and who were admitted to one of six pediatric hospitals serving a catchment area of 1.2 million children. We compared rates of admission and death with those among age-matched children who had been infected with seasonal influenza strains in previous years. RESULTS Between May and July 2009, a total of 251 children were hospitalized with 2009 H1N1 influenza. Rates of hospitalization were double those for seasonal influenza in 2008. Of the children who were hospitalized, 47 (19%) were admitted to an intensive care unit, 42 (17%) required mechanical ventilation, and 13 (5%) died. The overall rate of death was 1.1 per 100,000 children, as compared with 0.1 per 100,000 children for seasonal influenza in 2007. (No pediatric deaths associated with seasonal influenza were reported in 2008.) Most deaths were caused by refractory hypoxemia in infants under 1 year of age (death rate, 7.6 per 100,000). CONCLUSIONS Pandemic 2009 H1N1 influenza was associated with pediatric death rates that were 10 times the rates for seasonal influenza in previous years.

引用

页码：45 / 55

页数：11

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