Application of donor/acceptor-carbenoids to the synthesis of natural products

被引：383

作者：

Davies, Huw M. L. ^{[1
]}

Denton, Justin R. ^{[2
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

[2] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2009年 / 38卷 / 11期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

C-H ACTIVATION; ASYMMETRIC 4+3 CYCLOADDITIONS; ENANTIOSELECTIVE SYNTHESIS; ORGANIC-SYNTHESIS; CYCLOPROPANATION/COPE REARRANGEMENT; CATALYZED DECOMPOSITION; THREO-METHYLPHENIDATE; STRATEGIC REACTIONS; COPE REARRANGEMENT; INSERTION;

D O I：

10.1039/b901170f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The metal catalyzed reactions of diazo compounds have been broadly used in organic synthesis. The resulting metal-carbenoid intermediates are capable of undergoing a range of unconventional reactions, and due to their high energy, they are ideal for initiating cascade sequences leading to the rapid generation of structural complexity. This tutorial review will give an overview of the most versatile reactions of donor/acceptor carbenoids, an exciting class of intermediates capable of highly selective reactions. This will include cyclopropanation, [4 + 3] cycloaddition, and C-H functionalization methodologies. The application of this chemistry to the synthesis of a range of natural products will be described.

引用

页码：3061 / 3071

页数：11

共 46 条

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