Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients

被引：70

作者：

Michels, Sebastian ^{[1
,2
,3
]}

Scheel, Andreas Hans ^{[3
,4
]}

Scheffler, Matthias ^{[1
,2
,3
]}

Schultheis, Anne Maria ^{[3
,4
]}

Gautschi, Oliver ^{[5
]}

Aebersold, Franziska ^{[6
]}

Diebold, Joachim ^{[6
]}

Pall, Georg ^{[7
]}

Rothschild, Sacha ^{[8
]}

Bubendorf, Lukas ^{[9
]}

Hartmann, Wolfgang ^{[10
]}

Heukamp, Lukas ^{[3
,4
]}

Schildhaus, Hans-Ulrich ^{[11
]}

Fassunke, Jana ^{[3
,4
]}

Ihle, Michaela Angelika ^{[3
,4
]}

Kuenstlinger, Helen ^{[3
,4
]}

Heydt, Carina ^{[3
,4
]}

Fischer, Rieke ^{[1
,2
,3
]}

Nogova, Lucia ^{[1
,2
,3
]}

Mattonet, Christian ^{[1
,2
,3
]}

Hein, Rebecca ^{[12
]}

Adams, Anne ^{[12
]}

Gerigk, Ulrich ^{[13
]}

Schulte, Wolfgang ^{[14
]}

Lueders, Heike ^{[15
]}

Grohe, Christian ^{[15
]}

Graeven, Ullrich ^{[16
]}

Mueller-Naendrup, Clemens ^{[17
]}

Draube, Andreas ^{[18
]}

Kambartel, Karl-Otto ^{[19
]}

Krueger, Stefan ^{[20
]}

Schulze-Olden, Susanne ^{[20
]}

Serke, Monika ^{[21
]}

Engel-Riedel, Walburga ^{[22
]}

Kaminsky, Britta ^{[23
]}

Randerath, Winfried ^{[23
]}

Merkelbach-Bruse, Sabine ^{[3
,4
]}

Buettner, Reinhard ^{[3
,4
]}

Wolf, Juergen ^{[1
,2
,3
]}

机构：

[1] Ctr Integrated Oncol Koln Bonn, Cologne, Germany

[2] Univ Hosp Cologne, Dept Internal Med 1, Lung Canc Grp Cologne, Kerpener Str 62, D-50937 Cologne, Germany

[3] Network Genom Med, Cologne, Germany

[4] Univ Hosp Cologne, Inst Pathol, Kerpener Str 62, D-50937 Cologne, Germany

[5] Lucerne Cantonal Hosp, Dept Med Oncol, Luzern, Switzerland

[6] Lucerne Cantonal Hosp, Inst Pathol, Luzern, Switzerland

[7] Univ Innsbruck Hosp, Dept Internal Med Haematol & Oncol, A-6020 Innsbruck, Austria

[8] Univ Basel Hosp, Dept Oncol, CH-4031 Basel, Switzerland

[9] Univ Basel Hosp, Dept Cytopathol, CH-4031 Basel, Switzerland

[10] Univ Hosp Munster, Gerhard Domagk Inst Pathol, Munster, Germany

[11] Univ Hosp Gottingen, Inst Pathol, Gottingen, Germany

[12] Univ Hosp Cologne, Inst Med Stat Informat & Epidemiol, Kerpener Str 62, D-50937 Cologne, Germany

[13] Malteser Hosp Bonn Rhein Sieg, Thorac Ctr, Bonn, Germany

[14] Johanniter Hosp, Dept Pulmonol Cardiol & Allergol, Bonn, Germany

[15] Evangel Lung Clin Berlin, Dept Pneumol, Berlin, Germany

[16] Maria Hilt Hosp Monchengladbach, Dept Hematol Oncol & Gastroenterol, Monchengladbach, Germany

[17] Med Ctr II Martinus Hofe, Private Practice Oncol, Olpe, Germany

[18] St Vinzenz Hosp Cologne, Dept Internal Med, Cologne, Germany

[19] Bethanien Hosp Moers, Dept Pulmonol & Allergol, Moers, Germany

[20] Florence Nightingale Hosp, Dept Pulmonol Allergol Sleep Med & Resp Care, Dusseldorf, Germany

[21] Lung Clin Hemer, Dept Pulmonol & Thorac Oncol, Hemer, Germany

[22] Hosp Cologne, Lung Clin Merheim, Cologne, Germany

[23] Bethanien Hosp, Clin Pulmonol & Allergol, Solingen, Germany

来源：

JOURNAL OF THORACIC ONCOLOGY | 2016年 / 11卷 / 01期

关键词：

Adenocarcinoma; Clinicopathological characteristics; NSCLC; RET rearrangement; Smoking history; TP53; FUSIONS;

D O I：

10.1016/j.jtho.2015.09.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Rearrangements of RET are rare oncogenic events in patients with non-small cell lung cancer (NSCLC). While the characterization of Asian patients suggests a predominance of nonsmokers of young age in this genetically defined lung cancer subgroup, little is known about the characteristics of non-Asian patients. We present the results of an analysis of a European cohort of patients with RET rearranged NSCLC. Methods: Nine hundred ninety-seven patients with KRAS/EGFR/ALK wildtype lung adenocarcinomas were analyzed using fluorescence in situ hybridization for RET fusions. Tumor specimens were molecularly profiled and clinicopathological characteristics of the patients were collected. Results: Rearrangements of RET were identified in 22 patients, with a prevalence of 2.2% in the KRAS/EGFR/ALK wildtype subgroup. Co-occurring genetic aberrations were detected in 10 patients, and the majority had mutations in TP53. The median age at diagnosis was 62 years (range, 39-80 years; mean +/- SD, 61 +/- 11.7 years) with a higher proportion of men (59% versus 41%). There was only a slight predominance of nonsmokers (54.5%) compared to current or former smokers (45.5%). Conclusions: Patients with RET rearranged adenocarcinomas represent a rare and heterogeneous NSCLC sub-group. In some contrast to published data, we see a high prevalence of current and former smokers in our white RET cohort. The significance of co-occurring aberrations, so far, is unclear. (C) 2015 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

引用

页码：122 / +

页数：5

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