Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet

被引：0
作者：
Sakaida, I [1 ]
Yamasaki, T [1 ]
Terai, S [1 ]
Okita, K [1 ]
机构：
[1] Yamaguchi Univ, Sch Med, Dept Gastroenterol & Hepatol, Yamaguchi, Japan
来源：
ASIAN PACIFIC ASSOCIATION FOR THE STUDY OF THE LIVER MEETING 2002 | 2002年
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中图分类号：
R57 [消化系及腹部疾病];
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摘要：
The aim of this study was to investigate whether TJ-135 has any influence on the development of liver fibrosis in rats. The effects of the TJ-135 were examined using the choline-deficient L-amino acid-defined (CDAA) diet-induced liver fibrosis and human hepatic stellate cell line (LI90). TJ-135 prevented fibrosis in a dose-dependent manner up to 1.5% (w/w), as indicated by reduced hydroxyproline content in the liver, without reducing the increase in serum ALT. TJ-135 also reduced the number of activated stellate cells. With LI90 cells, TJ-135 reduced MAP kinase activities resulting in reduced PIIIP concentration in the medium in a dose-dependent manner. These results indicate that TJ-135 significantly reduces liver fibrosis through the inhibition of stellate cell activation.
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页码：153 / 158
页数：6
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