Amyloid beta protein and transthyretin, sequestrating protein colocalize in normal human kidney

被引：15
作者：
Tsuzuki, K
Fukatsu, R
Hayashi, Y
Yoshida, T
Sasaki, N
Takamaru, Y
Yamaguchi, H
Tateno, M
Fujii, N
Takahata, N
机构：
[1] SAPPORO MED UNIV,DEPT NEUROPSYCHIAT,SCH MED,SAPPORO,HOKKAIDO 060,JAPAN
[2] SAPPORO CITY GEN HOSP,DEPT PSYCHIAT,SAPPORO,HOKKAIDO 062,JAPAN
[3] GUNMA UNIV,COLL MED CARE & TECHNOL,GUNMA 371,JAPAN
[4] SAPPORO CITY GEN HOSP,DEPT PATHOL,SAPPORO,HOKKAIDO 060,JAPAN
来源：
NEUROSCIENCE LETTERS | 1997年 / 222卷 / 03期
关键词：
amyloid beta protein; amyloid precursor protein; proximal renal tubules; distal renal tubules human kidney; end-specific antibody; transthyretin;
D O I：
10.1016/S0304-3940(97)13369-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The localization of amyloid beta protein (A beta), A beta 40, A beta 42, and transthyretin (TTR) was investigated immunohistochemically in the autopsied human kidney, using polyclonal antibodies against TTR, A beta and C-terminal end-specific antibodies against A beta 40 and 42. Immunoreactivities of A beta and A beta 40 were found both in the proximal and distal tubular epithelial cells. But the immunolocalization of A beta 40 was observed predominantly in the distal tubules whereas that of A beta 42 was predominantly recognized in the proximal tubules. TTR, sequestrating protein for A beta, was present in the proximal tubules. The mechanism by which A beta does not form amyloid in Alzheimer's disease outside the brain remains unknown. The tubular epithelial cells in the kidney may provide a useful system to shed light on this issue. (C) 1997 Elsevier Science Ireland Ltd.
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收藏
页码：163 / 166
页数：4
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