Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane

被引：28

作者：

Clulow, James A. ^{[1
]}

Storck, Elisabeth M. ^{[1
]}

Lanyon-Hogg, Thomas ^{[1
]}

Kalesh, Karunakaran A. ^{[1
]}

Jones, Lyn H. ^{[2
]}

Tate, Edward W. ^{[1
]}

机构：

[1] Imperial Coll London, Dept Chem, London SW7 2AZ, England

[2] Pfizer, Med Design, 610 Main St, Cambridge, MA 02139 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 37期

基金：

英国工程与自然科学研究理事会;

关键词：

NF-KAPPA-B; PROTEIN LIPIDATION; EPITHELIAL-CELLS; GENE-EXPRESSION; ISOTHIOCYANATES; MECHANISMS; APOPTOSIS; CHEMOPREVENTION; INHIBITION; PREVENTION;

D O I：

10.1039/c6cc08797c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.

引用

页码：5182 / 5185

页数：4

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