Interleukin-12 gene polymorphisim in patients with giant cell arteritis, polymyalgia rheumatica and elderly-onset rheumatoid arthritis

被引:0
作者
Alvarez-Rodriguez, L. [1 ]
Martinez-Taboada, V. M. [1 ]
Lopez-Hoyos, M. [2 ]
Mata, C. [3 ]
Fernandez Prieto, L. [2 ]
Agudo-Bilbao, M. [1 ]
Calvo, J. [3 ]
Ruiz Soto, M. [1 ]
Rodriguez-Valverde, V. [1 ]
Ruiz, T. [3 ]
Blanco, R. [1 ]
Corrales, A. [4 ]
Carrasco-Marin, E. [2 ]
机构
[1] Univ Cantabria, Div Rheumatol, Hosp Univ Marques de Valdecilla, Fac Med, Santander 39008, Spain
[2] Univ Cantabria, Div Immunol, Hosp Univ Marques de Valdecilla, Fac Med, Santander 39008, Spain
[3] Hosp Sierrallana, Rheumatol Sect, IFIMAV, Fdn Marques de Valdecilla, Torrelavega, Spain
[4] Hosp Laredo, Rheumatol Unit, Cantabria, Spain
关键词
Giant cell arteritis; polymyalgia rheumatica; elderly onset rheumatoid arthritis; interleukin; 12; IL-12; P40; GENE; TAKAYASUS-ARTERITIS; CYTOKINE PRODUCTION; INTERFERON-GAMMA; DISEASE-ACTIVITY; SERUM CYTOKINE; SUSCEPTIBILITY; PROFILES; LYMPHOCYTES; HLA-DRB1;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. The cytokine profile suggests that giant cell arteritis (GCA) is a Th1-driven disease, in which local IFN-gamma plays a critical role in the development of a systemic arteritis. IL-12 is a potent inducer of IFN-gamma and is critically involved in biasing an immune response towards a Th1 pathway. The purpose of this study was to investigate whether there was an association between an IL-12 gene polymorphism (-1188 A/C 3'UTR) and disease susceptibility for GCA and two other age-related inflammatory conditions, such as polymyalgia rheumatica (PMR) and elderly-onset rheumatoid arthritis (EORA). Furthermore, we attempted to correlate such polymorphism with in vitro IL-12 production. Material and methods. We analyzed genotypes at -1188 in the 3'UTR of the IL-12 promoter by PCR-RFLP in 68 GCA, 138 PMR, and 72 EORA patients as well as in 465 healthy controls (HC). IL-12p70 levels in culture supernatants after stimulation with PMA + Ionomycin was assessed by ELISA. Results. All groups were in Hardy-Weinberg equilibrium. Allelic and genomic distribution was not significantly different among the study groups. None of the genetic variants was associated with disease severity. Although the differences were not statistically significant, HC genotypes were associated with distinct IL-12 p 70 production. Conclusions. The IL-12 (-1188 A/C 3'UTR) gene polymorphism is not associated with disease susceptibility or severity in three age-related chronic inflammatory syndromes. The production of IL-12 p70 is dependent on the genetic background in HC, although in patients such association may be biased by other unknown factors.
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页码:S14 / S18
页数:5
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