Determination of HIV drugs in biological matrices: A review

被引：19
作者：
Checa, Antonio [1 ]
Oliver, Ramon [2 ]
Hernandez-Cassou, Santiago [1 ]
Saurina, Javier [1 ]
机构：
[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain
[2] Univ Politecn Cataluna, Univ Sch Tech Engn Barcelona, Barcelona 08036, Spain
来源：
ANALYTICA CHIMICA ACTA | 2009年 / 647卷 / 01期
关键词：
Antiretroviral drugs; Biological matrices; High-performance liquid chromatography; Ultraviolet detection; Mass spectrometry/mass spectrometry detection; Validation; TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; REVERSE-TRANSCRIPTASE INHIBITORS; BLOOD MONONUCLEAR-CELLS; SOLID-PHASE EXTRACTION; CAPILLARY-ZONE-ELECTROPHORESIS; MS-MS METHOD; HUMAN PLASMA; PROTEASE INHIBITORS; ANTIRETROVIRAL DRUGS;
D O I：
10.1016/j.aca.2009.05.028
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The present paper reviews the recent advances on the determination of antiretroviral drugs against the human immunodeficiency virus (HIV). Methods have been reviewed with special emphasis on the principal analytical strategies for dealing with clinical samples as well as the determination of the newest drugs. The most critical steps of the analytical procedures including the sample treatment, separation and validation have been discussed. Finally, a brief description of representative applications is given. (C) 2009 Elsevier B.V. All rights reserved.
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页码：1 / 13
页数：13
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