Amine-promoted, organocatalytic aziridination of enones

被引：85

作者：

Armstrong, Alan ^{[1
]}

Baxter, Carl A.

Lamont, Scott G.

Pape, Andrew R.

Wincewicz, Richard

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/ol062852v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel method is presented using N-N ylides (prepared by in situ amination of a tertiary amine) for the aziridination of a range of enone systems. The amine may be used sub-stoichiometrically, and promising levels of enantioselectivity are observed with quinine as promoter.

引用

页码：351 / 353

页数：3

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