Amine-promoted, organocatalytic aziridination of enones

被引：83
作者：
Armstrong, Alan [1 ]
Baxter, Carl A.
Lamont, Scott G.
Pape, Andrew R.
Wincewicz, Richard
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England
[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1021/ol062852v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method is presented using N-N ylides (prepared by in situ amination of a tertiary amine) for the aziridination of a range of enone systems. The amine may be used sub-stoichiometrically, and promising levels of enantioselectivity are observed with quinine as promoter.
引用
收藏
页码：351 / 353
页数：3
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