Susceptibility to express amphetamine locomotor sensitization correlates with dorsolateral striatum bursting activity and GABAergic synapses in the globus pallidus

被引:2
作者
Ignacio Gatica, Rafael [1 ,2 ,3 ]
Aguilar-Rivera, Marcelo [4 ]
Henny, Pablo [2 ,3 ]
Antonio Fuentealba, Jose [1 ,3 ]
机构
[1] Pontificia Univ Catolica Chile, Fac Quim & Farm, Dept Farm, Lab Neuroquim, Santiago 7820244, Chile
[2] Pontificia Univ Catolica Chile, Escuela Med, Dept Anat, Lab Neuroanat, Santiago 8330023, Chile
[3] Pontificia Univ Catolica Chile, Ctr Interdisciplinario Neurociencia, Santiago 8330023, Chile
[4] Univ Calif San Diego, Dept Bioengn, San Diego, CA 92093 USA
关键词
Amphetamine; Basal ganglia; Dorsolateral striatum; Individual differences; Locomotor sensitization; BEHAVIORAL SENSITIZATION; INDIVIDUAL-DIFFERENCES; NEURAL INFORMATION; VULNERABILITY; ADDICTION; GLUTAMATE; PATHWAYS; PATTERNS; RELEASE; NEURONS;
D O I
10.1016/j.brainresbull.2021.12.005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Repeated psychostimulant administration results in behavioral sensitization, a process that is relevant in the early phases of drug addiction. Critically, behavioral sensitization is not observed in all subjects. Evidence shows that differential neuronal activity in the dorsolateral striatum (DLS) accompanies the expression of amphetamine (AMPH) locomotor sensitization. However, whether individual differences in DLS activity previous to AMPH administration can predict the expression of locomotor sensitization has not been assessed. Here, we examined DLS neuronal activity before and after repeated AMPH administration and related it to the susceptibility of rats to sensitize. For that, single-unit recordings on DLS medium spiny neurons (MSNs) were carried out in freely moving male Sprague Dawley rats during repeated AMPH administration. We also examined differences in neurostructure that could accompany sensitization. We quantified the density of the inhibitory postsynaptic marker gephyrin (Geph) in the entopeduncular nucleus (EP) and globus pallidus (GP). A higher burst firing and a lower percentage of correlation between MSNs post-Saline firing rate vs. locomotion predicted the expression of locomotor sensitization. Moreover, during the AMPH challenge, we observed that burst firing decreased in sensitized rats, in contrast to non-sensitized rats in which burst firing was maintained. Finally, a higher Geph density on GP but not EP was observed in non-sensitized rats after AMPH challenge. These results indicate that initial differences in DLS burst firing might underlie the susceptibility to express locomotor sensitization and suggest that the potentiation of dorsal striatum indirect pathway could be considered a protective mechanism to locomotor sensitization.
引用
收藏
页码:83 / 96
页数:14
相关论文
共 49 条
  • [1] Comparative Epidemiology of Dependence on Tobacco, Alcohol, Controlled Substances, and Inhalants: Basic Findings From the National Comorbidity Survey
    Anthony, James C.
    Warner, Lynn A.
    Kessler, Ronald C.
    [J]. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 1994, 2 (03) : 244 - 268
  • [2] ELECTROPHYSIOLOGICAL AND STRUCTURAL ALTERATIONS IN STRIATUM ASSOCIATED WITH BEHAVIORAL SENSITIZATION TO (±)3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY) IN RATS: ROLE OF DRUG CONTEXT
    Ball, K. T.
    Wellman, C. L.
    Miller, B. R.
    Rebec, G. V.
    [J]. NEUROSCIENCE, 2010, 171 (03) : 794 - 811
  • [3] Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information
    Barbera, Giovanni
    Liang, Bo
    Zhang, Lifeng
    Gerfen, Charles R.
    Culurciello, Eugenio
    Chen, Rong
    Li, Yun
    Lin, Da-Ting
    [J]. NEURON, 2016, 92 (01) : 202 - 213
  • [4] Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use
    Bock, Roland
    Shin, J. Hoon
    Kaplan, Alanna R.
    Dobi, Alice
    Markey, Eric
    Kramer, Paul F.
    Gremel, Christina M.
    Christensen, Christine H.
    Adrover, Martin F.
    Alvarez, Veronica A.
    [J]. NATURE NEUROSCIENCE, 2013, 16 (05) : 632 - +
  • [5] State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons
    Carter, AG
    Sabatini, BL
    [J]. NEURON, 2004, 44 (03) : 483 - 493
  • [6] Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons
    Cepeda, Carlos
    Andre, Veronique M.
    Yamazaki, Irene
    Wu, Nanping
    Kleiman-Weiner, Max
    Levine, Michael S.
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 27 (03) : 671 - 682
  • [7] L-type calcium channels modulate glutamate-driven bursting activity in the nucleus accumbens in vivo
    Cooper, DC
    White, FJ
    [J]. BRAIN RESEARCH, 2000, 880 (1-2) : 212 - 218
  • [8] The significance of action potential bursting in the brain reward circuit
    Cooper, DC
    [J]. NEUROCHEMISTRY INTERNATIONAL, 2002, 41 (05) : 333 - 340
  • [9] Concurrent activation of striatal direct and indirect pathways during action initiation
    Cui, Guohong
    Jun, Sang Beom
    Jin, Xin
    Pham, Michael D.
    Vogel, Steven S.
    Lovinger, David M.
    Costa, Rui M.
    [J]. NATURE, 2013, 494 (7436) : 238 - 242
  • [10] Evidence for addiction-like behavior in the rat
    Deroche-Gamonet, V
    Belin, D
    Piazza, PV
    [J]. SCIENCE, 2004, 305 (5686) : 1014 - 1017