Asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors: Synthesis and application in nitro-Mannich reaction of isatin-derived N-Boc ketimines

被引：22

作者：

Liu, Yuxin ^{[1
]}

Liu, Yu ^{[1
]}

Wang, Jingdong ^{[1
]}

Wei, Zhonglin ^{[1
]}

Cao, Jungang ^{[1
]}

Liang, Dapeng ^{[1
]}

Lin, Yingjie ^{[1
]}

Duan, Haifeng ^{[1
]}

机构：

[1] Jilin Univ, Dept Organ Chem, Coll Chem, 699 Qianjin St, Changchun 130012, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 24期

基金：

中国国家自然科学基金;

关键词：

(APT) catalysts; Bifunctional; Multiple hydrogen-bonding; Nitro-Mannich reaction; isatin-derived N-Boc ketimines; AZA-HENRY REACTION; ENANTIOSELECTIVE MICHAEL ADDITION; CYCLIC TRIFLUOROMETHYL KETIMINES; HIGHLY EFFICIENT; CINCHONA ALKALOIDS; BIFUNCTIONAL ORGANOCATALYST; CONSTRUCTION; DERIVATIVES; SQUARAMIDE; THIOUREAS;

D O I：

10.1016/j.tetlet.2017.05.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors derived from cinchona alkaloids are synthesized, and successfully applied to asymmetric nitro-Mannich of isatin-derived N-Boc ketimines. The products 3-substituted 3-amino-oxindoles were constructed in excellent yields (96-99%) and good enantioselectivities (up to 95% ee). (C) 2017 Published by Elsevier Ltd.

引用

页码：2400 / 2403

页数：4

共 55 条

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