A new 1,2,4-triazole acyclonucleosides: Synthesis and biological evaluation

被引：4

作者：

Radi, Smaail ^{[1
]}

Lazrek, Hassan B.

机构：

[1] Univ Mohamed I, Fac Sci, Dept Chim, Oujda, Morocco

[2] Fac Sci Semlalia, Chim Bioorgan Lab, Marrakech, Morocco

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2007年 / 4卷 / 03期

关键词：

nucleoside; triazole; catalysis; antiviral; ribavirin; acyclovir;

D O I：

10.2174/157018007780077372

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new regioisomers acyclonucleosides bearing 1,2,4-triazole rings as the base moiety were synthesised with aliphatic side chain [(2-acetoxyethoxy)methyl]-bromide under solid-liquid phase transfer catalysis (S.L.P.T.C.) and under silylation method. Biological evaluation of all product revealed they were inactive against various RNA and DNA viruses in cell cultures. Structure activity relationship studies (SAR) indicate that introduction of acyclovir arm in N1 or N2 position of 1,2,4-triazole has not any impact on the antiviral activity.

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收藏

页码：212 / 214

页数：3

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