Taxane Diterpenoids from Taiwanese Yew Taxus sumatrana

被引：3

作者：

Chuang, Chuan-Fu ^{[2
]}

Abd El-Razek, Mohamed H. ^{[1
]}

Kuo, Yuh-Chi ^{[3
]}

Chien, Ching-Te ^{[4
]}

Chou, Chang-Hung ^{[2
,5
]}

Shen, Ya-Ching ^{[1
]}

机构：

[1] Natl Taiwan Univ, Sch Pharm, Coll Med, Taipei 100, Taiwan

[2] Natl Sun Yat Sen Univ, Inst Biol, Kaohsiung, Taiwan

[3] Fu Jen Catholic Univ, Dept Life Sci, Hsinchuang 242, Taipei Hsien, Taiwan

[4] Taiwan Forestry Res Inst, Div Silviculture, Taipei, Taiwan

[5] China Med Univ, Grad Inst Ecol & Evolutionary Biol, Taichung 404, Taiwan

来源：

HELVETICA CHIMICA ACTA | 2009年 / 92卷 / 10期

关键词：

CHINESE YEW; MAIREI; TAXOIDS; CUSPIDATA; PRODUCTS; TREES;

D O I：

10.1002/hlca.200900164

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thirty seven taxanes were characterized from the leaves and twigs of Taiwanese yew (Taxus sumatrana, Taxaceae). Four of these metabolites are new and designated as sumataxins A-D (1-4). Compound 1. possesses an 11(15 -> 1),11(10 -> 9)-di-abeo-taxane skeleton with an unusual spiro-connected 2,2-dimethyl-1,3-dioxolane ring at C(4), whereas compound 2 has a rare P-OH orientation at C(13) of taxane diterpene ester. In addition, sumataxin C (3) is formulated as an 11(15 -> 1)-abeo-taxane with a 4,5-acetonide ring skeleton. Compound 4 is the first metabolite with a 4,20-epoxy-taxane structure. The structures of all the taxanes were established by spectroscopic methods. All compounds were evaluated for anti-HSV-1 and PBMC activities. Compound 9 exhibited significant enhancement of cell proliferation on peripheral blood mononuclear cells.

引用

页码：2134 / 2145

页数：12

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