Predictive Factors for Complete Response and Recurrence after Transarterial Chemoembolization in Hepatocellular Carcinoma

被引：65

作者：

Jeong, Shin Ok ^{[1
,2
]}

Kim, Eui Bae ^{[1
,2
]}

Jeong, Soung Won ^{[1
,2
]}

Jang, Jae Young ^{[1
,2
]}

Lee, Sae Hwan ^{[3
]}

Kim, Sang Gyune ^{[4
]}

Cha, Sang Woo ^{[1
,2
]}

Kim, Young Seok ^{[4
]}

Cho, Young Deok ^{[1
,2
]}

Kim, Hong Soo ^{[3
]}

Kim, Boo Sung ^{[1
,2
]}

Kim, Yong Jae ^{[5
]}

Goo, Dong Erk ^{[5
]}

Park, Su Yeon ^{[6
]}

机构：

[1] Soonchunhyang Univ Hosp, Dept Internal Med, Inst Digest Res, 59 Daesagwan Ro, Seoul 04401, South Korea

[2] Soonchunhyang Univ Hosp, Dept Internal Med, Digest Dis Ctr, 59 Daesagwan Ro, Seoul 04401, South Korea

[3] Soonchunhyang Univ Hosp, Dept Internal Med, Cheonan, South Korea

[4] Soonchunhyang Univ Hosp, Dept Internal Med, Bucheon, South Korea

[5] Soonchunhyang Univ Hosp, Dept Radiol, Seoul, South Korea

[6] Soonchunhyang Univ Hosp, Dept Biostat, Seoul, South Korea

来源：

GUT AND LIVER | 2017年 / 11卷 / 03期

关键词：

Carcinoma; hepatocellular; Chemoembolization; therapeutic; Complete response; Recurrence; RISK-FACTORS; LOCAL RECURRENCE; ABLATION; LIVER; THERAPY; HCC;

D O I：

10.5009/gnl16001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Methods: Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS). Results: Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43.2%). In multivariate analyses, tumor size (<= 5 cm) and single nodularity were predictive factors for CR, with hazard ratios (HRs) of 0.35 (p=0.002) and 0.41 (p < 0.001), respectively. Elevated serum a-fetoprotein (AFP) (> 20 ng/mL) level and multinodularity exhibited significant relationships with recurrence after CR, with HRs of 2.220 (p=0.026) and 3.887 (p < 0.001), respectively. Tumor size (> 5 cm), multinodularity, elevated serum AFP (> 20 ng/mL) level, Child-Turcotte-Pugh score (B and C), and portal vein thrombosis were significant factors for OS. Conclusions: In patients treated with TACE as a first therapy, tumor size (<= 5 cm) and single nodularity were predictive factors for CR, and multinodularity and elevated serum AFP (> 20 ng/mL) levels were predictive factors for recurrence after CR. These factors were also significant for OS.

引用

页码：409 / 416

页数：8

共 30 条

[1] Local recurrence is an important prognostic factor of hepatocellular carcinoma [J].