Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives

被引：50
作者：
Cocco, Maria T. [1 ]
Congiu, Cenzo [1 ]
Lilliu, Valentina [1 ]
Onnis, Valentina [1 ]
机构：
[1] Univ Cagliari, Dipartimento Tossicol, I-09124 Cagliari, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 04期
关键词：
pyridines; dicyanopyridines; anticancer activity; cytostatic activity;
D O I：
10.1016/j.bmc.2006.11.031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of 2-amino-4-aryl-6-dialkylamino-3,5-dicyanopyridines, 20-47, were synthesized in satisfactory overall yield, through a simple synthetic strategy using 3-amino-3-(dialkylamino)-propenenitriles 1 and 2 as key intermediates. 3,5-Dicyanopyridine derivatives 20-47 were evaluated for their in vitro anticancer activity toward cell lines of nine different types of human cancers. Some of the newly prepared compounds demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-6) M level and in some cases at 10(-8) M concentration. (c) 2006 Elsevier Ltd. All rights reserved.
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页码：1859 / 1867
页数：9
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