The T box mechanism: tRNA as a regulatory molecule

被引：106

作者：

Green, Nicholas J. ^{[1
]}

Grundy, Frank J. ^{[1
]}

Henkin, Tina M. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Microbiol, Ctr RNA Biol, Columbus, OH 43210 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Transcription attenuation; Antitermination; tRNA; Regulation; Riboswitch; MEDIATED TRANSCRIPTION ANTITERMINATION; SUBTILIS TYRS GENE; BACILLUS-SUBTILIS; IN-VITRO; LACTOCOCCUS-LACTIS; TERMINATION CONTROL; LEADER; SYNTHETASE; EXPRESSION; CONSERVATION;

D O I：

10.1016/j.febslet.2009.11.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The T box mechanism is widely used in Gram-positive bacteria to regulate expression of aminoacyl-tRNA synthetase genes and genes involved in amino acid biosynthesis and uptake. Binding of a specific uncharged tRNA to a riboswitch element in the nascent transcript causes a structural change in the transcript that promotes expression of the downstream coding sequence. In most cases, this occurs by stabilization of an antiterminator element that competes with formation of a terminator helix. Specific tRNA recognition by the nascent transcript results in increased expression of genes important for tRNA aminoacylation in response to decreased pools of charged tRNA. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：318 / 324

页数：7

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