Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria

被引：32

作者：

Schwenger, Katherine J. P. ^{[1
,2
]}

Bolzon, Colin M. ^{[2
]}

Li, Carrie ^{[2
]}

Allard, Johane P. ^{[2
,3
,4
]}

机构：

[1] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[2] Univ Hlth Network, Toronto Gen Hosp, 585 Univ Ave,9-973, Toronto, ON M5G 2C4, Canada

[3] Univ Toronto, Dept Med, Toronto, ON, Canada

[4] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada

来源：

EUROPEAN JOURNAL OF NUTRITION | 2019年 / 58卷 / 05期

关键词：

Non-alcoholic fatty liver disease; Obesity; Gut bacteria; Prebiotics; Fecal transplant; FECAL MICROBIOTA TRANSPLANTATION; INCREASED INTESTINAL PERMEABILITY; NF-KAPPA-B; INSULIN-RESISTANCE; BARIATRIC SURGERY; HEPATIC STEATOSIS; ADIPOSE-TISSUE; LEAN PATIENTS; STEATOHEPATITIS; ACTIVATION;

D O I：

10.1007/s00394-018-1844-5

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Non-alcoholic fatty-liver disease (NAFLD) is now considered one of the leading causes of liver disease worldwide and is associated with metabolic syndrome and obesity. There are several factors contributing to the disease state. Recent research suggests that the intestinal microbiota (IM) and bacterial products may play a role through several mechanisms which include increased energy uptake, intestinal permeability and chronic inflammation. In addition to diet and exercise, treatment options targeting the IM are being investigated and include the use of pre-, pro- and synbiotics as well as the possibility of fecal microbial transfers. This literature review explores the relationship between NAFLD and the IM as well as highlight new IM treatment options that may become available in the near future.

引用

页码：1771 / 1784

页数：14

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