Infections of the central nervous system: Neuropathology

被引:9
作者
Seilhean, D. [1 ]
机构
[1] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Neuropathol, 83 Blvd Hop,Batiment Paul Castaigne, F-75013 Paris, France
关键词
Encephalitis; Neuropathology; NGS; Metagenomics; Immunohistochemistry; In situ Hybridization; BRAIN BIOPSY; ACUTE ENCEPHALITIS; ETIOLOGIES; GUIDELINES; MANAGEMENT; DIAGNOSIS;
D O I
10.1016/j.neurol.2019.07.006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Encephalitides include a large variety of diseases with high morbidity and mortality. Although the majority of identified pathogens are viruses, the cause of the disease remains unexplained in more than half of the cases despite extensive testing. Neuropathology provides the bases of our understanding of the inflammatory lesions in the central nervous system. Brain biopsy proves to be necessary in cases of unknown etiology, which deteriorate despite treatment. Unexpected pathogens can be uncovered by untargeted transcriptomic analysis, based on deep sequencing of small quantities of pathological brain tissue. Combined with immunohistochemistry and in situ hybridization, using tailored antibodies and probes, this next generation sequencing method opens perspectives in the diagnosis of encephalitides with a high efficiency particularly in, but not limited to, immunocompromised patients. (C) 2019 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:431 / 435
页数:5
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