Developmental changes in UDP-N-acetylglucosamine 2-epimerase activity of rat and guinea-pig liver

被引：29

作者：

Gal, B

Ruano, MJ

Puente, R

GarciaPardo, LA

Rueda, R

Gil, A

Hueso, P

机构：

[1] UNIV SALAMANCA,FAC BIOL,DEPT BIOQUIM & BIOL MOL,EDIFICIO DEPARTAMENTAL LAB 103,E-37007 SALAMANCA,SPAIN

[2] UNIV LEON,FAC VET,DEPT FISIOL FARMACOL & TOXICOL,E-24071 LEON,SPAIN

[3] ABBOTT LABS,DEPT INVEST & DESARROLLO,GRANADA 18004,SPAIN

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1997年 / 118卷 / 01期

关键词：

guinea-pig; liver; rat; sialic acid; UDP-N-acetylglucosamine; 2-epimerase; development;

D O I：

10.1016/S0305-0491(97)00016-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of UDP-N-acetylglucosamine 2-epimerase was determined in the liver of rats and guinea-pigs of different ages. The activity of this enzyme in rats was low at birth, increased to a maximum value on day 15, and fell gradually until day 30. Thereafter, it increased up to the 60th day. The activity profile of the enzyme from guinea-pig liver was very similar. However, guinea-pig activity was 2-5 times lower than in rats. Both rats and guinea-pigs displayed similar liver sialic acid contents which increased from birth to 2 months of age. Rats also showed a N-glycolylneuraminic acid content that decreased from birth to 2 months. From these results we can inferred that postnatal UDP-N-acetylglucosamine 2 epimerase activity seems to be correlated with age and the developmental states of rats and guinea-pigs. (C) 1997 Elsevier Science Inc.

引用

页码：13 / 15

页数：3

共 14 条

[1]

Corfield A.P., 1982, CELL BIOL MONOGR, V10, P195

[2]

KIKUCHI K, 1986, BIOCHIM BIOPHYS ACTA, V252, P357

[3]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[4] DEVELOPMENTAL SIALIC-ACID MODIFICATIONS IN RAT ORGANS [J].