A new citryl glycoside from Gastrodia elata and its inhibitory activity on GABA transaminase

被引：23

作者：

Choi, Jung-Hyun ^{[1
]}

Lee, Dong-Ung ^{[1
]}

机构：

[1] Dongguk Univ, Dept Biotechnol, Gyeongju 780714, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 12期

关键词：

Gastrodia elata; Orchidaceae; trimethylcitryl-beta-D-galactopyranoside; gastrodigenin; GABA transaminase;

D O I：

10.1248/cpb.54.1720

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new citryl glycoside, trimethylcitryi-beta-D-galactopyranoside (1) along with a known phenolic compound, gastrodigenin (2) have been isolated from the active fraction of the rhizomes of Gastrodia elata (Orchidaceae). Their structures were elucidated on the basis of spectroscopic data and chemical reaction. 1 inhibited GABA transaminase activity by 56.8% at the final concentration of 10 mu g/ml.

引用

页码：1720 / 1721

页数：2

共 20 条

[1]

BERGMEYER HU, 1983, METHOD ENZYMATIC ANA, V2, P1690

[2]

Ha JeoungHee, 1999, Korean Journal of Pharmacognosy, V30, P284

[3]

Ha JeoungHee, 1999, Korean Journal of Pharmacognosy, V30, P211

[4] 4-hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain [J].

Ha, JH ;

Lee, DU ;

Lee, JT ;

Kim, JS ;

Yong, CS ;

Kim, JA ;

Ha, JS ;

Huh, K .

JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (1-2) :329-333

[5] In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation [J].

Ha, JH ;

Shin, SM ;

Lee, SK ;

Kim, JS ;

Shin, US ;

Huh, K ;

Kim, JA ;

Yong, CS ;

Lee, NJ ;

Lee, DU .

PLANTA MEDICA, 2001, 67 (09) :877-880

[6]

HA JH, 1997, J APPL PHARM, V5, P325

[7] Gastrodia elata prevents rat pheochromocytoma cells from serum-deprived apoptosis:: the role of the MAPK family [J].

Huang, NK ;

Lin, YL ;

Cheng, JJ ;

Lai, WL .

LIFE SCIENCES, 2004, 75 (13) :1649-1657

[8]

Huh Keun, 1998, Yakhak Hoeji, V42, P330

[9] Isolation of 3-O-(4′-hydroxybenzyl)-β-sitosterol and 4-[4′-(4′′-hydroxybenzyloxy)benzyloxy]benzyl methyl ether from fresh tubers of Gastrodia elata [J].

Hye, SYC ;

Pyo, MK ;

Park, KM .

ARCHIVES OF PHARMACAL RESEARCH, 1998, 21 (03) :357-360

[10] Anxiolytic-Like effects of Gastrodia elata and its phenolic constituents in mice [J].

Jung, JW ;

Yoon, BH ;

Oh, HR ;

Ahn, JH ;

Kim, SY ;

Park, SY ;

Ryu, JF .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (02) :261-265

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