Favoritism in DNA Methylation

被引：1

作者：

Hitchins, Megan P. ^{[1
]}

Ward, Robyn L. ^{[1
]}

机构：

[1] Univ New S Wales, Lowy Canc Res Ctr, Prince Wales Clin Sch, Kensington, NSW 2033, Australia

来源：

CANCER PREVENTION RESEARCH | 2009年 / 2卷 / 10期

关键词：

MGMT PROMOTER METHYLATION; X-CHROMOSOME INACTIVATION; COLORECTAL-CANCER; GENE; EXPRESSION; REPAIR; HYPERMETHYLATION; MUTATIONS; FAMILIES; DISEASE;

D O I：

10.1158/1940-6207.CAPR-09-0178

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This perspective on Candiloro and Dobrovic (beginning on p. 862 in this issue of the journal) highlights the interplay between epigenetic aberrations and underlying DNA sequence changes and illustrates how these alterations may predispose individuals to cancer. Candiloro and Dobrovic clearly show that particular genotypes of the MGMT gene are associated with its methylation in healthy individuals. Aberrant MGMT methylation may identify individuals who could be targeted for cancer screening and chemoprevention strategies.

引用

页码：847 / 849

页数：3

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