Reactions of pyrazoles and pyrazolium salts with complex metal hydrides and organometallic reagents. Synthesis of pyrazolines and pyrazolidines.

被引：14

作者：

Cuadrado, P ^{[1
]}

GonzalezNogal, AM ^{[1
]}

Martinez, S ^{[1
]}

机构：

[1] UNIV VALLADOLID,DEPT QUIM ORGAN,E-47011 VALLADOLID,SPAIN

来源：

TETRAHEDRON | 1997年 / 53卷 / 25期

关键词：

D O I：

10.1016/S0040-4020(97)00514-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Pyrazolin-4-oximes have been synthesized by reaction of 4-nitroso- and 4-nitropyrazoles with complex metal hydrides and organometallic reagents. Furthermore, 4-nitropyrazolium tetrafluoroborates are reactive substrates towards organolithium and Grignard compounds leading to new and highly substituted 4-nitro-3-pyrazolines and 4-nitropyrazolidines. The formation of 3-pyrazolines is regioselective and, when diastereoisomer pyrazolidines are possible, only the most stable 3,4-trans and/or 4,5-trans isomers were obtained. (C) 1997 Elsevier Science Ltd.

引用

页码：8585 / 8598

页数：14

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