Regioselective synthesis of multisubstituted isoquinolones and pyridones via Rh(III)-catalyzed annulation reactions

被引：118

作者：

Shi, Liangliang ^{[1
]}

Yu, Ke ^{[1
]}

Wang, Baiquan ^{[1
,2
,3
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 97期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; CASCADE OXIDATIVE ANNULATION; N-N BOND; RHODIUM(III)-CATALYZED SYNTHESIS; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; INTERNAL ALKYNES; INDOLE SYNTHESIS; DIAZO-COMPOUNDS; CARBENOID FUNCTIONALIZATION;

D O I：

10.1039/c5cc05977a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and efficient Rh(III)-catalyzed regioselective synthesis of isoquinolones and pyridones has been developed. The protocol uses readily available N-methoxybenzamide or N-methoxymethacryl-amide and diazo compounds as starting materials. The process involving tandem C-H activation, cyclization, and condensation steps proceeds under mild conditions, and the corresponding isoquinolone and pyridone derivatives were obtained in good to excellent yields with excellent regioselectivities. The process provides a facile approach for the construction of isoquinolone and pyridone derivatives containing various functional groups.

引用

页码：17277 / 17280

页数：4

共 115 条

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