Toward the Establishment of New Clinical Endpoints for Cystic Fibrosis: The Role of Lung Clearance Index and Cardiopulmonary Exercise Testing

被引：8

作者：

Hatziagorou, Elpis ^{[1
]}

Kampouras, Asterios ^{[1
]}

Avramidou, Vasiliki ^{[1
]}

Toulia, Ilektra ^{[1
]}

Chrysochoou, Elisavet-Anna ^{[1
]}

Galogavrou, Maria ^{[1
]}

Kirvassilis, Fotios ^{[1
]}

Tsanakas, John ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Hippokrat Hosp, Pediat Pulmonol & Cyst Fibrosis Unit, Thessaloniki, Greece

来源：

FRONTIERS IN PEDIATRICS | 2021年 / 9卷

关键词：

lung clearance index (LCI); cardiopulmonary exercise testing (CPET); endpoints; cystic fibrosis; disease severity; disease progression; INERT-GAS WASHOUT; MULTIPLE-BREATH WASHOUT; YOUNG-CHILDREN; VENTILATION INHOMOGENEITY; COMPUTED-TOMOGRAPHY; PRESCHOOL-CHILDREN; PROGNOSTIC VALUE; DOUBLE-BLIND; DISEASE; IVACAFTOR;

D O I：

10.3389/fped.2021.635719

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

As Cystic Fibrosis (CF) treatment advances, research evidence has highlighted the value and applicability of Lung Clearance Index and Cardiopulmonary Exercise Testing as endpoints for clinical trials. In the context of these new endpoints for CF trials, we have explored the use of these two test outcomes for routine CF care. In this review we have presented the use of these methods in assessing disease severity, disease progression, and the efficacy of new interventions with considerations for future research.

引用

页数：7

共 105 条

[1] The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis
Amin, R.
Subbarao, P.
Lou, W.
Jabar, A.
Balkovec, S.
Jensen, R.
Kerrigan, S.
Gustafsson, P.
Ratjen, F.
[J]. EUROPEAN RESPIRATORY JOURNAL, 2011, 37 (04) : 806 - 812
[2] Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function
Amin, Reshma
Subbarao, Padmaja
Jabar, Alisha
Balkovec, Susan
Jensen, Renee
Kerrigan, Shawn
Gustafsson, Per
Ratjen, Felix
[J]. THORAX, 2010, 65 (05) : 379 - 383
[3] Normative data for multiple breath washout outcomes in school-aged Caucasian children
Anagnostopoulou, Pinelopi
Latzin, Philipp
Jensen, Renee
Stahl, Mirjam
Harper, Alana
Yammine, Sophie
Usemann, Jakob
Foong, Rachel E.
Spycher, Ben
Hall, Graham L.
Singer, Florian
Stanojevic, Sanja
Mall, Marcus A.
Ratjen, Felix
Ramsey, Kathryn A.
[J]. EUROPEAN RESPIRATORY JOURNAL, 2020, 55 (04)
[4] STANDARDISATION OF LUNG CLEARANCE INDEX IN A MULTICENTRE CLINICAL TRIAL
Armstrong, D. K.
Bayfield, K. J.
Alton, E. W. F. W.
Boyd, A. C.
Cunningham, S.
Elgmati, H. I.
Gill, D. R.
Griesenbach, U.
Higgins, T. E.
Hyde, S. C.
Innes, J. A.
Saunders, C. J.
Spearing, E. J.
Davies, J. C.
[J]. THORAX, 2014, 69 : A168 - A169
[5] Gas mixing efficiency from birth to adulthood measured by multiple-breath washout
Aurora, P
Kozlowska, W
Stocks, J
[J]. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2005, 148 (1-2) : 125 - 139
[6] Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis
Aurora, P
Gustafsson, P
Bush, A
Lindblad, A
Oliver, C
Wallis, CE
Stocks, J
[J]. THORAX, 2004, 59 (12) : 1068 - 1073
[7] Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis
Aurora, P
Bush, A
Gustafsson, P
Oliver, C
Wallis, C
Price, J
Stroobant, J
Carr, S
Stocks, J
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (03) : 249 - 256
[8] Lung Clearance Index at 4 Years Predicts Subsequent Lung Function in Children with Cystic Fibrosis
Aurora, Paul
Stanojevic, Sanja
Wade, Angie
Oliver, Cara
Kozlowska, Wanda
Lum, Sooky
Bush, Andrew
Price, John
Carr, Siobhan B.
Shankar, Anu
Stocks, Janet
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (06) : 752 - 758
[9] Avramidou V., 2017, J PULM RESP MED, V6, P392
[10] Lung clearance index (LCI) as a predictor of exercise limitation among CF patients
Avramidou, Vasiliki
Hatziagorou, Elpis
Kampouras, Asterios
Hebestreit, Helge
Kourouki, Eleana
Kirvassilis, Fotis
Tsanakas, John
[J]. PEDIATRIC PULMONOLOGY, 2018, 53 (01) : 81 - 87

← 1 2 3 4 5 6 7 8 9 10 →