Toward the Establishment of New Clinical Endpoints for Cystic Fibrosis: The Role of Lung Clearance Index and Cardiopulmonary Exercise Testing

被引：8

作者：

Hatziagorou, Elpis ^{[1
]}

Kampouras, Asterios ^{[1
]}

Avramidou, Vasiliki ^{[1
]}

Toulia, Ilektra ^{[1
]}

Chrysochoou, Elisavet-Anna ^{[1
]}

Galogavrou, Maria ^{[1
]}

Kirvassilis, Fotios ^{[1
]}

Tsanakas, John ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Hippokrat Hosp, Pediat Pulmonol & Cyst Fibrosis Unit, Thessaloniki, Greece

来源：

FRONTIERS IN PEDIATRICS | 2021年 / 9卷

关键词：

lung clearance index (LCI); cardiopulmonary exercise testing (CPET); endpoints; cystic fibrosis; disease severity; disease progression; INERT-GAS WASHOUT; MULTIPLE-BREATH WASHOUT; YOUNG-CHILDREN; VENTILATION INHOMOGENEITY; COMPUTED-TOMOGRAPHY; PRESCHOOL-CHILDREN; PROGNOSTIC VALUE; DOUBLE-BLIND; DISEASE; IVACAFTOR;

D O I：

10.3389/fped.2021.635719

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

As Cystic Fibrosis (CF) treatment advances, research evidence has highlighted the value and applicability of Lung Clearance Index and Cardiopulmonary Exercise Testing as endpoints for clinical trials. In the context of these new endpoints for CF trials, we have explored the use of these two test outcomes for routine CF care. In this review we have presented the use of these methods in assessing disease severity, disease progression, and the efficacy of new interventions with considerations for future research.

引用

页数：7

共 105 条

[1] The effect of dornase alfa on ventilation inhomogeneity in patients with cystic fibrosis [J].

Amin, R. ;

Subbarao, P. ;

Lou, W. ;

Jabar, A. ;

Balkovec, S. ;

Jensen, R. ;

Kerrigan, S. ;

Gustafsson, P. ;

Ratjen, F. .

EUROPEAN RESPIRATORY JOURNAL, 2011, 37 (04) :806-812

[2] Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function [J].

Amin, Reshma ;

Subbarao, Padmaja ;

Jabar, Alisha ;

Balkovec, Susan ;

Jensen, Renee ;

Kerrigan, Shawn ;

Gustafsson, Per ;

Ratjen, Felix .

THORAX, 2010, 65 (05) :379-383

[3] Normative data for multiple breath washout outcomes in school-aged Caucasian children [J].

Anagnostopoulou, Pinelopi ;

Latzin, Philipp ;

Jensen, Renee ;

Stahl, Mirjam ;

Harper, Alana ;

Yammine, Sophie ;

Usemann, Jakob ;

Foong, Rachel E. ;

Spycher, Ben ;

Hall, Graham L. ;

Singer, Florian ;

Stanojevic, Sanja ;

Mall, Marcus A. ;

Ratjen, Felix ;

Ramsey, Kathryn A. .

EUROPEAN RESPIRATORY JOURNAL, 2020, 55 (04)

[4] STANDARDISATION OF LUNG CLEARANCE INDEX IN A MULTICENTRE CLINICAL TRIAL [J].

Armstrong, D. K. ;

Bayfield, K. J. ;

Alton, E. W. F. W. ;

Boyd, A. C. ;

Cunningham, S. ;

Elgmati, H. I. ;

Gill, D. R. ;

Griesenbach, U. ;

Higgins, T. E. ;

Hyde, S. C. ;

Innes, J. A. ;

Saunders, C. J. ;

Spearing, E. J. ;

Davies, J. C. .

THORAX, 2014, 69 :A168-A169

[5] Gas mixing efficiency from birth to adulthood measured by multiple-breath washout [J].

Aurora, P ;

Kozlowska, W ;

Stocks, J .

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2005, 148 (1-2) :125-139

[6] Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis [J].

Aurora, P ;

Gustafsson, P ;

Bush, A ;

Lindblad, A ;

Oliver, C ;

Wallis, CE ;

Stocks, J .

THORAX, 2004, 59 (12) :1068-1073

[7] Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis [J].

Aurora, P ;

Bush, A ;

Gustafsson, P ;

Oliver, C ;

Wallis, C ;

Price, J ;

Stroobant, J ;

Carr, S ;

Stocks, J .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (03) :249-256

[8] Lung Clearance Index at 4 Years Predicts Subsequent Lung Function in Children with Cystic Fibrosis [J].

Aurora, Paul ;

Stanojevic, Sanja ;

Wade, Angie ;

Oliver, Cara ;

Kozlowska, Wanda ;

Lum, Sooky ;

Bush, Andrew ;

Price, John ;

Carr, Siobhan B. ;

Shankar, Anu ;

Stocks, Janet .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (06) :752-758

[9]

Avramidou V., 2017, J PULM RESP MED, V6, P392

[10] Lung clearance index (LCI) as a predictor of exercise limitation among CF patients [J].

Avramidou, Vasiliki ;

Hatziagorou, Elpis ;

Kampouras, Asterios ;

Hebestreit, Helge ;

Kourouki, Eleana ;

Kirvassilis, Fotis ;

Tsanakas, John .

PEDIATRIC PULMONOLOGY, 2018, 53 (01) :81-87

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