Individual water-soluble dendrimer-encapsulated silver nanodot fluorescence

被引:563
作者
Zheng, J [1 ]
Dickson, RM [1 ]
机构
[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
关键词
D O I
10.1021/ja028282l
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Easily observed on the single molecule level, highly fluorescent and photostable silver nanoclusters have been photochemically prepared within poly(amidoamine) dendrimer hosts in aqueous solutions. The dendrimer cage stabilizes and solubilizes the nanoclusters to yield highly stable, photoactivated single nanodots ranging in size from 2 to 8 silver atoms. These multicolored, highly fluorescent species are extremely photostable and readily observed on the single molecule scale with weak mercury lamp excitation. Such easily created, bright, photoactivated water-soluble fluorophores are likely to greatly expand the impact of single molecule labeling studies in a wide variety of systems. Copyright © 2002 American Chemical Society.
引用
收藏
页码:13982 / 13983
页数:2
相关论文
共 25 条
[1]   Imaging three-dimensional single molecule orientations [J].
Bartko, AP ;
Dickson, RM .
JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (51) :11237-11241
[2]   Three-dimensional single molecule rotational diffusion in glassy state polymer films [J].
Bartko, AP ;
Xu, KW ;
Dickson, RM .
PHYSICAL REVIEW LETTERS, 2002, 89 (02) :261011-261014
[3]   Near-infrared luminescence from small gold nanocrystals [J].
Bigioni, TP ;
Whetten, RL ;
Dag, Ö .
JOURNAL OF PHYSICAL CHEMISTRY B, 2000, 104 (30) :6983-6986
[4]   Ab initio study of the absorption spectra of Agn (n=5-8) clusters [J].
Bonacic-Koutecky, V ;
Veyret, V ;
Mitric, R .
JOURNAL OF CHEMICAL PHYSICS, 2001, 115 (22) :10450-10460
[5]   Semiconductor nanocrystals as fluorescent biological labels [J].
Bruchez, M ;
Moronne, M ;
Gin, P ;
Weiss, S ;
Alivisatos, AP .
SCIENCE, 1998, 281 (5385) :2013-2016
[6]   Quantum dot bioconjugates for ultrasensitive nonisotopic detection [J].
Chan, WCW ;
Nie, SM .
SCIENCE, 1998, 281 (5385) :2016-2018
[7]   Dendrimer-encapsulated metal nanoparticles: Synthesis, characterization, and applications to catalysis [J].
Crooks, RM ;
Zhao, MQ ;
Sun, L ;
Chechik, V ;
Yeung, LK .
ACCOUNTS OF CHEMICAL RESEARCH, 2001, 34 (03) :181-190
[8]   On/off blinking and switching behaviour of single molecules of green fluorescent protein [J].
Dickson, RM ;
Cubitt, AB ;
Tsien, RY ;
Moerner, WE .
NATURE, 1997, 388 (6640) :355-358
[9]   Single-molecule spectroscopy of the conjugated polymer MEH-PPV [J].
Hu, DH ;
Yu, J ;
Barbara, PF .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (29) :6936-6937
[10]   Single molecule detection using surface-enhanced Raman scattering (SERS) [J].
Kneipp, K ;
Wang, Y ;
Kneipp, H ;
Perelman, LT ;
Itzkan, I ;
Dasari, R ;
Feld, MS .
PHYSICAL REVIEW LETTERS, 1997, 78 (09) :1667-1670