Toward the Synthesis of Benzothiazolyl Fluoroaminosulfones

被引：32

作者：

Calata, Charlene

Pfund, Emmanuel

Lequeux, Thierry ^{[1
]}

机构：

[1] Univ Caen Basse Normandie, Lab Chim Mol& Thioorgan, CNRS, UMR 6507, F-14050 Caen, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 24期

关键词：

AZA-MICHAEL ADDITION; FLUOROOLEFIN DIPEPTIDE ISOSTERES; ALKYL RADICAL-ADDITION; HIGH-YIELD SYNTHESIS; JULIA OLEFINATION; STEREOSELECTIVE CONSTRUCTION; ENANTIOSELECTIVE SYNTHESIS; HIGHLY EFFICIENT; AROMATIC-AMINES; WEINREB AMIDES;

D O I：

10.1021/jo901540c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Due to the importance of allylamines in organic synthesis, the synthesis of reagents as potent precursors of aminofluoroolefins is reported from functionalized benzothiazolylsulfones. The key intermediate, a fluorovinyl sulfone, was prepared and functionalized by addition of aliphatic, aromatic amines and amino acid alkyl esters through an aza-Michael addition reaction.

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页码：9399 / 9405

页数：7

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