Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

被引:9
作者
Phromnoi, Kanokkarn [1 ]
Sinchaiyakij, Puksiri [2 ]
Khanaree, Chakkrit [3 ]
Nuntaboon, Piyawan [1 ]
Chanwikrai, Yupa [2 ]
Chaiwangsri, Thida [4 ]
Suttajit, Maitree [1 ]
机构
[1] Univ Phayao, Sch Med Sci, Div Biochem, Mueang 56000, Phayao, Thailand
[2] Univ Phayao, Sch Med Sci, Div Nutr, Mueang 56000, Phayao Province, Thailand
[3] Chiangrai Rajabhat Univ, Sch Tradit & Alternat Med, Mueang 57100, Chiangrai, Thailand
[4] Univ Phayao, Sch Med Sci, Div Microbiol & Parasitol, Mueang 56000, Phayao Province, Thailand
关键词
anti-inflammatory; antioxidants; medicinal plants; traditional healers; antiulcer; PSIDIUM-GUA[!text type='JAVA']JAVA[!/text] L; INDUCED GASTRIC-ULCERS; IN-VITRO; CAREYA-ARBOREA; NITRIC-OXIDE; ACUTE-PANCREATITIS; GHRELIN; EXTRACT; INHIBITION; PATHOPHYSIOLOGY;
D O I
10.3390/scipharm87030022
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
For centuries, many kinds of native plants and their products have been used for the treatment of gastric ulcers by traditional healers in Phayao province. The current study aimed to investigate the polyphenol content in some of these medicinal plants and to point out the relationship between their antioxidant capacity and anti-inflammatory activities. Six species were selected based on ethnopharmacologic considerations: Punica granatum L., Psidium guajava L., Careya arborea Roxb., Gochnatia decora (Kurz) Cabr., Shorea obtusa Wall. ex Blume, and Ficus hispida L.f. The leaves or bark of these plants were extracted with 70% ethanol and water. Anti-inflammatory and antioxidant activities of the extracts were analyzed based on nitric oxide (NO) and proinflammatory cytokine production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and through the determination of scavenging activity. The results demonstrated that the ethanol extract from P. granatum and P. guajava leaves significantly inhibited NO production by suppressing nitric oxide synthase. The extracts also inhibited tumor necrosis factor-alpha, interleukin-1, and interleukin-6 in terms of both mRNA and protein levels and possessed high antioxidants. These extracts were shown to contain the highest amount of polyphenols. Our study concluded that among the plants studied, P. granatum and P. guajava have the most significant anti-inflammatory and antioxidant activities and polyphenols. These plants may have the potential for use in gastric ulcer therapy due to their indicated properties. Future research should focus on the isolation of their active compounds and their in vivo biological activities. Their beneficial applications need to be warranted by such evidence.
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页数:12
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