The development of intellectual abilities in pediatric temporal lobe epilepsy

被引:131
作者
Cormack, Francesca
Cross, J. Helen
Isaacs, Elizabeth
Harkness, William
Wright, Ingram
Vargha-Khadem, Faraneh
Baldeweg, Torsten
机构
[1] UCL, Inst Child Hlth, Dev Cognit Neurosci Unit, London WC1N 1EH, England
[2] UCL, Inst Child Hlth, Neurosci Unit, London WC1N 1EH, England
[3] Great Ormond St Hosp Sick Children, London, England
[4] UCL, MRC, Inst Child Hlth, Childhood Nutr Res Ctr, London, England
[5] Univ Sheffield, Dept Psychol, Clin Psychol Unit, Sheffield, S Yorkshire, England
基金
英国医学研究理事会;
关键词
pediatric epilepsy; temporal lobe; intelligence; age at onset;
D O I
10.1111/j.1528-1167.2006.00904.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: The aim of this study was to examine the impact of clinical variables, particularly age at onset of epilepsy, on intellectual function in a group of children with temporal lobe epilepsy (TLE). Methods: We reviewed the preoperative neuropsychological test results of 79 children with unilateral TLE who subsequently underwent surgical resection. The impact of age at onset and duration of epilepsy, pathology type, and side of resection on full-scale intelligence quotient (IQ) scores was examined. Results: Intellectual dysfunction (defined as IQ < 79) was present in 57% of children, and age at onset of epilepsy was the best predictor of intellectual function. Children with epilepsy onset in the first year of life had a particularly high incidence of intellectual impairment (82.4%). Conclusion: These data suggest a critical period during the first year of life for the subsequent development of intellectual abilities and highlight the importance of early treatment in this population.
引用
收藏
页码:201 / 204
页数:4
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