Prediction of symptom remission in schizophrenia during inpatient treatment

被引：20

作者：

Jaeger, Markus ^{[1
]}

Riedel, Michael ^{[1
]}

Schmauss, Max ^{[2
]}

Laux, Gerd ^{[3
]}

Pfeiffer, Herbert

Naber, Dieter ^{[4
]}

Schmidt, Lutz G. ^{[5
]}

Gaebel, Wolfgang ^{[6
]}

Klosterkoetter, Joachim ^{[7
]}

Heuser, Isabella ^{[8
]}

Kuehn, Kai-Uwe ^{[9
]}

Lemke, Matthias R. ^{[10
]}

Ruether, Eckart ^{[11
]}

Buchkremer, Gerd ^{[12
]}

Gastpar, Markus ^{[13
]}

Bottlender, Ronald ^{[1
]}

Strauss, Anton ^{[1
]}

Moeller, Hans-Juergen ^{[1
]}

机构：

[1] Univ Munich, Dept Psychiat, D-8000 Munich, Germany

[2] Dist Hosp, Psychiat Clin, Augsburg, Germany

[3] Dist Hosp Gabersee, Psychiat Clin, Wasserburg am Inn, Germany

[4] Univ Hamburg, Dept Psychiat, Hamburg, Germany

[5] Johannes Gutenberg Univ Mainz, Dept Psychiat, D-6500 Mainz, Germany

[6] Univ Dusseldorf, Dept Psychiat, D-4000 Dusseldorf, Germany

[7] Univ Cologne, Dept Psychiat, D-5000 Cologne 41, Germany

[8] Charite, Dept Psychiat, Berlin, Germany

[9] Univ Bonn, Dept Psychiat, D-5300 Bonn, Germany

[10] Rhein Kliniken, Psychiat Clin, Bonn, Germany

[11] Univ Gottingen, Dept Psychiat, D-3400 Gottingen, Germany

[12] Univ Tubingen, Dept Psychiat, D-72074 Tubingen, Germany

[13] Univ Essen Gesamthsch, Dept Psychiat, Essen, Germany

来源：

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | 2009年 / 10卷 / 04期

关键词：

Schizophrenia; remission; PANSS; prediction; negative symptoms; ACUTE NEUROLEPTIC TREATMENT; TREATMENT RESPONSE; 1ST EPISODE; CRITERIA; ABNORMALITIES; RISPERIDONE; PROGNOSIS; 1-YEAR; SCALE;

D O I：

10.3109/15622970701541054

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Standardized consensus criteria for remission in schizophrenia were recently proposed. The present study applied the symptom-severity component of these criteria to a sample of inpatients in order to determine the rates of remission during inpatient treatment and to explore predictors of remission. Method: A total of 288 inpatients from a multi-centre follow-up programme who fulfilled ICD-10 criteria for schizophrenia were included in the present analyses. PANSS ratings at admission and at discharge from hospitalization were used to examine remission status. Clinical and sociodemographic variables at admission were tested for their ability to predict remission at discharge. Results: In total, 55% of the sample achieved symptom remission during inpatient treatment; 84% percent showed remission with respect to 'reality distortion', 85% with respect to 'disorganization' and only 65% with respect to 'negative symptoms'. Logistic regression analysis revealed that the global functioning (GAF) in the year before admission, the total score of the Strauss-Carpenter Prognostic Scale and the PANSS negative subscore at admission were predictive for symptom remission. The regression model showed a predictive value of about 70% and explained 36% of the observed variance. Conclusion: The results highlight the impact of negative symptoms for the course and treatment response of schizophrenic illness.

引用

页码：426 / 434

页数：9

共 49 条

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