A practical, efficient, and rapid method for the oxidation of electron deficient pyridines using trifluoroacetic anhydride and hydrogen peroxide-urea complex

被引:72
作者
Caron, S [1 ]
Do, NM [1 ]
Sieser, JE [1 ]
机构
[1] Pfizer Inc, Pfizer Cent Res, Proc Res & Dev, Groton, CT 06340 USA
关键词
oxidation; pyridines; N-oxides; peroxides;
D O I
10.1016/S0040-4039(00)00165-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A general method for the oxidation of electron-poor pyridines to their N-oxides using UHP and TFAA in either CH2Cl2 or CH3CN was developed. The methodology proved to tolerate a number of functional groups and substitution patterns and proceeded on notoriously difficult to oxidize substrates. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2299 / 2302
页数:4
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