Prospects for 3D bioprinting of organoids

被引：61

作者：

Rawal, Preety ^{[1
,2
]}

Tripathi, Dinesh M. ^{[1
]}

Ramakrishna, Seeram ^{[3
]}

Kaur, Savneet ^{[1
]}

机构：

[1] Inst Liver & Biliary Sci ILBS, Dept Mol & Cellular Med, D1 Vasant Kunj, New Delhi 110070, India

[2] Gautam Buddha Univ, Sch Biotechnol, Greater Noida, India

[3] Natl Univ Singapore, Dept Mech Engn, Singapore, Singapore

来源：

BIO-DESIGN AND MANUFACTURING | 2021年 / 4卷 / 03期

关键词：

Three-dimensional bioprinting; Bioink; Organoid; Microfluidics; Extracellular matrix (ECM); Biomaterial; EXTRACELLULAR-MATRIX; STEM-CELLS; IN-VITRO; BIOINK; MODEL; GENERATION;

D O I：

10.1007/s42242-020-00124-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Three-dimensional (3D) organoids derived from pluripotent or adult tissue stem cells seem to possess excellent potential for studying development and disease mechanisms alongside having a myriad of applications in regenerative therapies. However, lack of precise architectures and large-scale tissue sizes are some of the key limitations of current organoid technologies. 3D bioprinting of organoids has recently emerged to address some of these impediments. In this review, we discuss 3D bioprinting with respect to the use of bioinks and bioprinting methods and highlight recent studies that have shown success in bioprinting of stem cells and organoids. We also summarize the use of several vascularization strategies for the bioprinted organoids, that are critical for a complex tissue organization. To fully realize the translational applications of organoids in disease modeling and regenerative medicine, these areas in 3D bioprinting need to be appropriately harnessed and channelized.

引用

页码：627 / 640

页数：14

共 62 条

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