Epac inhibits apoptosis of human leukocytes

被引：19

作者：

Grandoch, M. ^{[1
]}

Bujok, V. ^{[1
]}

Fleckenstein, D. ^{[1
]}

Schmidt, M. ^{[2
]}

Fischer, J. W. ^{[1
]}

Weber, A. -A. ^{[1
]}

机构：

[1] Univ Klinikum Essen, Inst Pharmakol, D-45122 Essen, Germany

[2] Univ Groningen, Dept Mol Pharmacol, Groningen, Netherlands

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2009年 / 86卷 / 04期

关键词：

U937; cell; TNF-alpha; cAMP; signal transduction; DEPENDENT PROTEIN-KINASE; LEUKEMIA CELL-LINE; CYCLIC-AMP; ACTIVATION; CAMP; NEUTROPHILS; EXPRESSION; PATHWAY;

D O I：

10.1189/jlb.0109048

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

cAMP is known to participate in the regulation of apoptosis in leukocytes. Depending on the cell type, pro- and antiapoptotic effects of cAMP have been described. Thus far, most of the cAMP-dependent effects have been attributed to the activation of PKA. However, Epac proteins (direct cAMP targets and guanine nucleotide exchange factors for Ras-like GTPases) have been shown recently to contribute to cAMP-dependent regulation of apoptosis. Therefore, we investigated the effects of the selective Epac activators 8-pCPT and Sp on apoptosis in human leukocytic cells (U937, HL-60, primary human mononuclear cells). We report here that Epac activation inhibits leukocyte apoptosis significantly. J. Leukoc. Biol. 86: 847-849; 2009.

引用

页码：847 / 849

页数：3

共 13 条

[11] Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of caspase-3 [J].

Parvathenani, LK ;

Buescher, ES ;

Chacon-Cruz, E ;

Beebe, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) :6736-6743

[12] Membrane environment rather than tissue factor expression determines thrombin formation triggered by monocytic cells undergoing apoptosis [J].

Stampfuss, Jan Julius ;

Censarek, Petra ;

Bein, Daniela ;

Schroer, Karsten ;

Grandoch, Maria ;

Naber, Christoph ;

Weber, Artur-Aron .

JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 83 (06) :1379-1381

[13] Protein kinase a regulates expression of p27kip1 and cyclin D3 to suppress proliferation of leukemic T cell lines [J].

van Oirschot, BA ;

Stahl, M ;

Lens, SMA ;

Medema, RH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :33854-33860

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