Reactive oxygen species, mitochondria, apoptosis and aging

被引：412
作者：
Papa, S
Skulachev, VP
机构：
[1] MOSCOW MV LOMONOSOV STATE UNIV, AN BELOZERSKY INST PHYSICOCHEM BIOL, MOSCOW 119899, RUSSIA
[2] UNIV BARI, INST MED BIOCHEM & CHEM, I-70124 BARI, ITALY
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1997年 / 174卷 / 1-2期
关键词：
mitochondrial metabolism; mitochondrial DNA; superoxide radicals;
D O I：
10.1023/A:1006873518427
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this paper, we shall review various antioxygen defense systems of the cell paying particular attention to those that prevent superoxide formation rather than scavenge already formed superoxide and its products. The role of uncoupled, decoupled and non-coupled respiration, mitochondrial pore, mitochondrion-linked apoptosis will be considered. Mitochondrial theory of aging will be regarded in context of reactive oxygen species-induced damage of mitochondrial DNA.
引用
收藏
页码：305 / 319
页数：15
相关论文
共 156 条
[1]  
AMES BN, 1991, OXIDATIVE DAMAGE & REPAIR, P181
[2]   SEQUENCE AND ORGANIZATION OF THE HUMAN MITOCHONDRIAL GENOME [J].
ANDERSON, S ;
BANKIER, AT ;
BARRELL, BG ;
DEBRUIJN, MHL ;
COULSON, AR ;
DROUIN, J ;
EPERON, IC ;
NIERLICH, DP ;
ROE, BA ;
SANGER, F ;
SCHREIER, PH ;
SMITH, AJH ;
STADEN, R ;
YOUNG, IG .
NATURE, 1981, 290 (5806) :457-465
[3]   OXYGEN ACTIVATION AND THE CONSERVATION OF ENERGY IN CELL RESPIRATION [J].
BABCOCK, GT ;
WIKSTROM, M .
NATURE, 1992, 356 (6367) :301-309
[4]   ACONITASE, A 2-FACED PROTEIN - ENZYME AND IRON REGULATORY FACTOR [J].
BEINERT, H ;
KENNEDY, MC .
FASEB JOURNAL, 1993, 7 (15) :1442-1449
[5]   RECENT PROGRESS ON REGULATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE - A CYCLOSPORINE-SENSITIVE PORE IN THE INNER MITOCHONDRIAL-MEMBRANE [J].
BERNARDI, P ;
BROEKEMEIER, KM ;
PFEIFFER, DR .
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1994, 26 (05) :509-517
[6]  
BERNARDI P, 1992, J BIOL CHEM, V267, P8834
[7]   A 3D MODEL OF THE PERIPHERAL BENZODIAZEPINE RECEPTOR AND ITS IMPLICATION IN INTRA MITOCHONDRIAL CHOLESTEROL TRANSPORT [J].
BERNASSAU, JM ;
REVERSAT, JL ;
FERRARA, P ;
CAPUT, D ;
LEFUR, G .
JOURNAL OF MOLECULAR GRAPHICS, 1993, 11 (04) :236-244
[8]   REDOX-LINKED PROTON TRANSLOCATION IN CYTOCHROME-OXIDASE - THE IMPORTANCE OF GATING ELECTRON FLOW - THE EFFECTS OF SLIP IN A MODEL TRANSDUCER [J].
BLAIR, DF ;
GELLES, J ;
CHAN, SI .
BIOPHYSICAL JOURNAL, 1986, 50 (04) :713-733
[9]   DECLINE WITH AGE OF THE RESPIRATORY-CHAIN ACTIVITY IN HUMAN SKELETAL-MUSCLE [J].
BOFFOLI, D ;
SCACCO, SC ;
VERGARI, R ;
SOLARINO, G ;
SANTACROCE, G ;
PAPA, S .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1994, 1226 (01) :73-82
[10]   Ageing is associated in females with a decline in the content and activity of the b-c(1) complex in skeletal muscle mitochondria [J].
Boffoli, D ;
Scacco, SC ;
Vergari, R ;
Persio, MT ;
Solarino, G ;
Laforgia, R ;
Papa, S .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1996, 1315 (01) :66-72
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