Synthesis, spectral and structural characterization of dinuclear rhodium (II) complexes of the anticonvulsant drug valproate with theophylline and caffeine

被引：29

作者：

Abuhijleh, A. Latif ^{[1
]}

Abu Ali, Hijazi ^{[1
]}

Emwas, Abdul-Hamid ^{[2
]}

机构：

[1] Birzeit Univ, Dept Chem, W Bank, Israel

[2] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2009年 / 694卷 / 22期

关键词：

Rhodium (II) valproate; Theophylline; Caffeine; Dinuclear; Bis-adducts; X-ray crystal structure; NUCLEIC-ACID BASES; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE; ANTITUMOR AGENT; METAL-COMPLEXES; DONOR LIGANDS; ADDUCTS; DNA; GUANINE; BINDING;

D O I：

10.1016/j.jorganchem.2009.07.031

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The dinuclear complex tetra(mu-valproato) dirhodium(II), Rh-2(valp)(4) (1), and its bis-adducts with theophylline, Rh-2(valp)(4)(ThH)(2) (4), or caffeine, Rh-2(valp)(4)(Caf)(2) (5), have been synthesized and characterized by elemental analysis, IR, UV-Vis, magnetic moment, H-1 and C-13 NMR spectroscopic techniques. Spectral data for the complexes are consistent with a dinuclear structure as found for rhodium (II) tetracarboxylate adducts. Theophylline and caffeine bases in complexes 4 and 5, respectively, are axially coordinated to rhodium (II) atoms through the sterically hindered N(9) site. This is confirmed by X-ray crystal structure analyses of complexes 4 and 5. (C) 2009 Elsevier B. V. All rights reserved.

引用

页码：3590 / 3596

页数：7

共 40 条

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