Serum free fatty acids and glucose metabolism, insulin resistance in schizophrenia with chronic antipsychotics

被引:29
作者
Wang, Cong-jie
Zhang, Zhi-jun [1 ]
Sun, Jing
Zhang, Xiao-bing
Mou, Xiao-dong
Zhang, Xiang-rong
Shang, Xiao-fang
Zhang, Tai-quan
机构
[1] SE Univ, Affiliated Zhongda Hosp, Dept Neurol, Nanjing 210009, Jiangsu Provinc, Peoples R China
[2] Huaian 3 Hosp, Dept Psychiat, Huaian, Jiangsu Provinc, Peoples R China
[3] Nanjing Med Univ, Affiliated Brain Hosp, Dept Psychiat, Nanjing, Jiangsu Provinc, Peoples R China
[4] Wangzhou Wutaishan Hosp, Dept Psychiat, Yangzhou, Jiangsu Provinc, Peoples R China
[5] Suzhou Puji Hosp, Dept Psychiat, Suzhou, Jiangsu Provinc, Peoples R China
关键词
fasting blood glucose; insulin resistance; schizophrenia; serum free fatty acids;
D O I
10.1016/j.biopsych.2006.03.014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background Weight gain and type 2 diabetes mellitus (DM) are often linked to antipsychotics treatment. The aim of the study is to investigate serum free fatty acids (FFA) levels in schizophrenic patients who received long-term. antipsychotics treatment, and to explore the associations between serum FFA and fasting blood glucose, and insulin resistance. Methods: 308 inpatients with schizophrenia who met with the criteria of DSM-IV were recruited into this study, and were divided into four groups: control subjects, single obesity, impaired glucose tolerance (IGT) and type 2 DM according to different body mass index, fasting blood glucose level and 2-hour postprandial blood glucose, Serum FFA was measured with colorimetry. Serum insulin and leptin were measured with radioimmunoassay respectively. Results: There was a significant elevation in serum FFA levels in schizophrenic patients who received long-term antipsychotics treatment, especially in single obesity, IGT, and DM groups. The elevated serum FFA was remarkably positive correlated with fasting blood glucose and insulin resistance. Conclusions: The study suggested the elevated serum FFA in schizophrenic patients with long-term antipsychotics treatment affected the blood glucose metabolism, may have played an important role in insulin resistance and type 2 DM, and was also all important trait of metabolic syndromes.
引用
收藏
页码:1309 / 1313
页数:5
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