Simultaneous occurrence of anti-BP180 mucous membrane pemphigoid and mucosal-dominant pemphigus vulgaris

被引:4
作者
Kobayashi, K. [1 ]
Tanaka, M. [1 ]
Nakajima, S. [1 ]
Ito, H. [1 ]
Harada, T. [1 ]
Hashimoto, T. [2 ]
机构
[1] Tokyo Womens Med Univ, Med Ctr E, Dept Dermatol, Tokyo, Japan
[2] Kurume Univ, Sch Med, Dept Dermatol, Fukuoka, Japan
关键词
ANTIGEN; AUTOANTIBODIES; ANTIBODIES; BP180; TOOL;
D O I
10.1111/j.1365-2230.2009.03513.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
We describe the simultaneous initial coexistence of mucous membrane pemphigoid (MMP) with blepharosynechia and anti-bullous pemphigoid (BP) 180 antibodies and pemphigus vulgaris (PV) with lesions limited to the oral mucosa, with the presence of anti-desmoglein (Dsg) 3 antibodies. A 75-year-old woman had severe oropharyngeal erosions and ulcers with blisters, and blepharoconjunctivitis and blepharosynechia of the left eye. Histopathological examination of the oral mucosa found acantholysis. Indirect immunofluorescence revealed IgG antikeratinocyte cell surface antibodies, and ELISA disclosed anti-Dsg3 antibodies. Immunoblotting found positive reactivity with recombinant proteins of both the BP180-NC16a domain and the BP180 C-terminal domain. To our knowledge, the simultaneous initial occurrence of MMP and PV has never been reported previously. We present a rare case of concurrent PV and anti-BP180 MMP, the diagnosis of which was confirmed by ELISA and immunoblotting assays.
引用
收藏
页码:E785 / E788
页数:4
相关论文
共 10 条
[1]   Coexistence of pemphigus vulgaris and ocular cicatricial pemphigoid [J].
Buhac, J ;
Bhol, K ;
Padilla, T ;
Foster, CS ;
Ahmed, AR .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1996, 34 (05) :884-886
[2]   PEMPHIGUS-LIKE ANTIBODIES IN CICATRICIAL PEMPHIGOID [J].
CRAM, DL ;
GRIFFITH, MR ;
FUKUYAMA, K .
ARCHIVES OF DERMATOLOGY, 1974, 109 (02) :235-238
[3]   DETECTION OF PEMPHIGUS VULGARIS AND PEMPHIGUS FOLIACEUS ANTIGENS BY IMMUNOBLOT ANALYSIS USING DIFFERENT ANTIGEN SOURCES [J].
HASHIMOTO, T ;
OGAWA, MM ;
KONOHANA, A ;
NISHIKAWA, T .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (03) :327-331
[4]   Usefulness of immunoblotting using purified laminin 5 in the diagnosis of anti-laminin 5 cicatricial pemphigoid [J].
Hisamatsu, Y ;
Nishiyama, T ;
Amano, S ;
Matsui, C ;
Ghohestani, R ;
Hashimoto, T .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2003, 33 (02) :113-119
[5]  
Ishii K, 1997, J IMMUNOL, V159, P2010
[6]   BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid [J].
Kobayashi, M ;
Amagai, M ;
Kuroda-Kinoshita, K ;
Hashimoto, T ;
Shirakata, Y ;
Hashimoto, K ;
Nishikawa, T .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2002, 30 (03) :224-232
[7]   The majority of bullous pemphigoid and herpes gestations serum samples read with the NC16a domain of the 180-kDa bullous pemphigoid antigen [J].
Matsumura, K ;
Amagai, M ;
Nishikawa, T ;
Hashimoto, T .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 1996, 288 (09) :507-509
[8]   IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180 [J].
Nie, ZX ;
Hashimoto, T .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 112 (02) :254-255
[9]   RETRACTED: Simultaneous presence of mucous membrane pemphigoid and pemphigus vulgaris: Molecular characterization of both autoantibodies (Retracted Article) [J].
Sami, N ;
Bhol, KC ;
Beutner, EH ;
Plunkett, RW ;
Leiferman, KM ;
Foster, CS ;
Ahmed, AR .
CLINICAL IMMUNOLOGY, 2001, 100 (02) :219-227
[10]   Enzyme-linked immunosorbent assay using bacterial recombinant proteins of human BP230 as a diagnostic tool for bullous pemphigoid [J].
Yoshida, M ;
Hamada, T ;
Amagai, M ;
Hashimoto, K ;
Uehara, R ;
Yamaguchi, K ;
Imamura, K ;
Okamoto, E ;
Yasumoto, S ;
Hashimoto, T .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2006, 41 (01) :21-30