Intraoperative radiotherapy for the treatment of thyroid cancer: a pilot study

被引：5

作者：

Yi, Pei-Qiang ^{[1
]}

Nie, Fang-Fang ^{[1
]}

Fan, You-Ben ^{[5
]}

Yu, Wei-Wei ^{[1
]}

Hu, Chao-su ^{[2
,3
]}

Guo, Xiao-Mao ^{[2
,4
]}

Fu, Jie ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiat Oncol, Shanghai, Peoples R China

[2] Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai, Peoples R China

[3] Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China

[4] Fudan Univ, Shanghai Med Coll, Shanghai, Peoples R China

[5] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Surg, Shanghai, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 17期

关键词：

thyroid cancer; intraoperative radiotherapy; pilot study; radiation therapy; adverse reactions; BEAM RADIATION-THERAPY; LONG-TERM OUTCOMES; TARGIT-A TRIAL; BREAST-CANCER; EXTERNAL RADIOTHERAPY; EXPERIENCE; METASTASIS; NECK;

D O I：

10.18632/oncotarget.12901

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We preliminarily evaluated the clinical feasibility and efficacy of intraoperative radiotherapy in patients with thyroid carcinoma. Nine thyroid cancer patients received intraoperative radiotherapy using an Intrabeam system. The dose was 3-4 Gy and the irradiation time ranged from 1 min 32 s to 7 min 33s. One case was a primary thyroid carcinoma, while the other cases were recurrent disease. Adverse effects, recurrence and survival were analyzed. In one patient, poorly differentiated thyroid carcinoma recurred 5 months after treatment, one patient developed a postoperative tracheal skin fistula, and one patient developed a wound infection. Because the affected areas were treated with both surgical resection and then radiotherapy, it is difficult to know which of those led to the adverse effects. Nonetheless, our results indicate that intraoperative radiotherapy can relieve the symptoms associated with thyroid cancer and improve the quality of life for these patients. It thus appears feasible to treat thyroid cancer patients with intraoperative radiotherapy.

引用

页码：29355 / 29360

页数：6

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