Trimethyl chitosan postoperative irrigation solution modulates inflammatory cytokines related to adhesion formation

被引：11

作者：

Abueva, Celine D. G. ^{[1
,2
]}

Ryu, Hyun Seok ^{[3
]}

Park, So Young ^{[1
]}

Lee, Hayoung ^{[3
]}

Padalhin, Andrew R. ^{[1
]}

Min, Jun Won ^{[4
]}

Chung, Phil-Sang ^{[1
,2
,5
]}

Woo, Seung Hoon ^{[1
,2
,5
]}

机构：

[1] Dankook Univ, Beckman Laser Inst Korea, Coll Med, Cheonan, South Korea

[2] Dankook Univ, Med Laser Res Ctr, Cheonan, South Korea

[3] Dankook Univ, Interdisciplinary Program Med Laser, Cheonan, South Korea

[4] Dankook Univ, Dept Surg, Coll Med, Cheonan, South Korea

[5] Dankook Univ, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, 201 Manghyang Ro, Cheonan 31116, South Korea

来源：

CARBOHYDRATE POLYMERS | 2022年 / 288卷

基金：

新加坡国家研究基金会;

关键词：

Irrigation; Anti-inflammatory; Anti-adhesion; Trimethyl chitosan; Chitosan; NECROSIS-FACTOR-ALPHA; BIOMEDICAL APPLICATIONS; PERITONEAL ADHESIONS; PREVENTION; COMPLEXES; HYDROGEL; LAVAGE; NASAL; FLUID; SITE;

D O I：

10.1016/j.carbpol.2022.119380

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Lavage or irrigation has been instilled in surgical practice for wound clearance and surgical site infection prevention during and after surgery. Herein, we developed a new irrigation solution using trimethyl chitosan (TMC), a quaternized chitosan derivative. The TMC-saline irrigation solution developed in the study possesses highly effective bactericidal properties with hemostatic and anti-adhesion properties. The anti-adhesion property of TMC was investigated in relation to inflammatory cytokine response and wound healing. TMC-saline irrigation solution showed reduced pro-inflammatory cytokine protein and gene expressions relevant in the cascade of wound healing and cytokine-related orchestration of postoperative adhesion formation. Further development of this multifunctional TMC-saline irrigation solution can be beneficial for surgical applications and postoperative wound management.

引用

页数：11

共 43 条

[1] Quaternary ammonium N,N,N-trimethyl chitosan derivative and povidone-iodine complex as a potent antiseptic with enhanced wound healing property [J].