Sex-gender-related therapeutic approaches for cardiovascular complications associated with diabetes

被引：59

作者：

Campesi, Ilaria ^{[1
]}

Franconi, Flavia ^{[1
,2
]}

Seghieri, Giuseppe ^{[3
]}

Meloni, Marco ^{[4
]}

机构：

[1] Univ Sassari, Dept Biomed Sci, Sassari, Italy

[2] Reg Basilicata, Dipartimento Polit Persona, Potenza, Italy

[3] AUSL3, Ctr Studi Salute Genere, Pistoia, Italy

[4] Univ Edinburgh, Queens Med Res Inst, BHF Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland

来源：

PHARMACOLOGICAL RESEARCH | 2017年 / 119卷

关键词：

Diabetes mellitus; Sex-gender differences; Risk factors; Cardiovascular complications; Therapeutic approaches; ACUTE MYOCARDIAL-INFARCTION; PERIPHERAL ARTERIAL-DISEASE; CORONARY-HEART-DISEASE; ENDOTHELIAL PROGENITOR CELLS; HORMONE-REPLACEMENT THERAPY; ALL-CAUSE MORTALITY; RISK-FACTORS; INSULIN SENSITIVITY; THROMBOLYTIC THERAPY; POSTMENOPAUSAL WOMEN;

D O I：

10.1016/j.phrs.2017.01.023

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetes is a chronic disease associated with micro- and macrovascular complications and is a well established risk factor for cardiovascular disease. Cardiovascular complications associated with diabetes are among the most important causes of death in diabetic patients. Interestingly, several sex-gender differences have been reported to significantly impact in the pathophysiology of diabetes. In particular, sex-gender differences have been reported to affect diabetes epidemiology, risk factors, as well as cardiovascular complications associated with diabetes. This suggests that different therapeutic approaches are needed for managing diabetes-associated cardiovascular complications in men and women. In this review, we will discuss about the sex-gender differences that are known to impact on diabetes, mainly focusing on the cardiovascular complications associated with the disease. We will then discuss the therapeutic approaches for managing diabetes-associated cardiovascular complications and how differences in sex-gender can influence the existing therapeutic approaches. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：195 / 207

页数：13

共 282 条

[1] Sex differences in the association between plasma copeptin and incident type 2 diabetes: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study [J].