Subcellular mRNA Localization in Animal Cells and Why It Matters

被引：296

作者：

Holt, Christine E. ^{[2
]}

Bullock, Simon L. ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Div Cell Biol, Cambridge CB2 0QH, England

[2] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3DY, England

来源：

SCIENCE | 2009年 / 326卷 / 5957期

基金：

英国惠康基金;

关键词：

XENOPUS-OOCYTES; PROTEIN-SYNTHESIS; ACTIN; TRANSLATION; TRANSPORT; DROSOPHILA; REVEALS; TRAFFICKING; TRANSLOCATION; DETERMINANTS;

D O I：

10.1126/science.1176488

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Subcellular localization of messenger RNAs (mRNAs) can give precise control over where protein products are synthesized and operate. However, just 10 years ago many in the broader cell biology community would have considered this a specialized mechanism restricted to a very small fraction of transcripts. Since then, it has become clear that subcellular targeting of mRNAs is prevalent, and there is mounting evidence for central roles for this process in many cellular events. Here, we review current knowledge of the mechanisms and functions of mRNA localization in animal cells.

引用

页码：1212 / 1216

页数：5

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