Recent advances and future directions in amphiphilic cyclodextrin nanoparticles

被引:93
作者
Bilensoy, Erem [1 ]
Hincal, A. Atilla [1 ]
机构
[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey
关键词
amphiphilic cyclodextrin; encapsulation; nanoparticle; preparation; synthesis; PROGESTERONE INCLUSION COMPLEXES; HYDROXYPROPYL-BETA-CYCLODEXTRIN; LANGMUIR-BLODGETT-FILMS; PHARMACEUTICAL APPLICATIONS; ALPHA-CYCLODEXTRIN; DRUG-DELIVERY; GENE DELIVERY; PHYSICOCHEMICAL PROPERTIES; ORAL BIOAVAILABILITY; ANIONIC PORPHYRINS;
D O I
10.1517/17425240903222218
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cyclodextrins are known to be promising excipients in the pharmaceutical industry, with their ability to include hydrophobic guest molecules masking the physicochemical properties of the guest, such as poor water solubility, stability problems and undesired side effects. These enabling excipients, which are produced on a large scale and incorporated into various marketed products worldwide, are now modified to render amphiphilic properties that enable them to be used to prepare nanoparticles. Amphiphilic cyclodextrins have the ability to form nanoparticles without the presence of a surfactant by different preparation techniques that are discussed in this review. Classification and physicochemical properties of these interesting molecules as well as the efficacy and safety of nanoparticles prepared from different amphiphilic cyclodextrins are discussed in light of the current literature work with in vitro and in vivo findings. Cyclodextrin nanoparticles of different nature effectively carry drugs or molecules with bioavailability problems arising from poor aqueous solubility, stability under physiological conditions or side effects associated with the molecule itself or excipients used in the formulation of these problems drugs. In conclusion, amphiphilic cyclodextrins emerge as promising alternatives for tumor drug delivery and passive and active targeting with non-toxic, non-hemolytic properties as injectable, nanosized carriers.
引用
收藏
页码:1161 / 1173
页数:13
相关论文
共 98 条
  • [1] Sulfated and non-sulfated amphiphilic-β-cyclodextrins:: Impact of their structural properties on the physicochemical properties of nanoparticles
    Abdelwahed, Wassim
    Degobert, Ghania.
    Dubes, Alix
    Parrot-Lopez, Helene
    Fessi, Hatem
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 351 (1-2) : 289 - 295
  • [2] Cyclodextrin derivatives in pharmaceutics
    Albers, E
    Muller, BW
    [J]. CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 1995, 12 (04): : 311 - 337
  • [3] Scanning force microscopy investigation of amphiphilic cyclodextrin Langmuir-Blodgett films
    Alexandre, S
    Coleman, AW
    Kasselouri, A
    Valleton, JM
    [J]. THIN SOLID FILMS, 1996, 284 : 765 - 768
  • [4] Sulphated sugar alpha-cyclodextrin sulphate, a uniquely potent anti-HIV agent, also exhibits marked synergism with AZT, and Iymphoproliferative activity
    Anand, R.
    Nayyar, S.
    Pitha, J.
    Merril, C. R.
    [J]. ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1990, 1 (01) : 41 - 46
  • [5] Micellization of hydrophobically modified cyclodextrins.: 1.: Micellar structure
    Auzély-Velty, R
    Djedaïni-Pilard, F
    Désert, S
    Perly, B
    Zemb, T
    [J]. LANGMUIR, 2000, 16 (08) : 3727 - 3734
  • [6] NMR INVESTIGATIONS OF THE CONFORMATION OF NEW CYCLODEXTRIN-BASED AMPHIPHILIC TRANSPORTERS FOR HYDROPHOBIC DRUGS - MOLECULAR LOLLIPOPS
    BELLANGER, N
    PERLY, B
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 1992, 273 : 215 - 226
  • [7] Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery
    Bellocq, NC
    Pun, SH
    Jensen, GS
    Davis, ME
    [J]. BIOCONJUGATE CHEMISTRY, 2003, 14 (06) : 1122 - 1132
  • [8] Development of nonsurfactant cyclodextrin nanoparticles loaded with anticancer drug paclitaxel
    Bilensoy, Erem
    Gurkaynak, Oya
    Ertan, Mevlut
    Sen, Murat
    Hincal, A. Atilla
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (04) : 1519 - 1529
  • [9] Safety and efficacy of amphiphilic β-cyclodextrin nanoparticles for paclitaxel delivery
    Bilensoy, Erem
    Gurkaynak, Oya
    Dogan, A. Lale
    Hincal, A. Atilla
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 347 (1-2) : 163 - 170
  • [10] Complexation behavior of antiestrogen drug tamoxifen citrate with natural and modified β-cyclodextrins
    Bilensoy, Erem
    Dogan, Lale
    Sen, Murat
    Hincal, Atilla
    [J]. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2007, 57 (1-4) : 651 - 655