Promising novel therapies for the treatment of endometrial cancer

Objectives. To discuss the novel agents which are being developed for the treatment of advanced and recurrent endometrial carcinoma and to review other molecular targets that may be interesting in the treatment of this disease. While the majority of women with endometrial cancer enjoy a relatively good prognosis, the options for those women who Suffer from a disease recurrence are limited and there is a need to identify novel agents. Methods. A review of clinical trials of novel therapeutic agents and then molecular targets is provided. In addition, a review of the current literature on other potential molecular targets for endometrial cancer was performed. Results. Several phase II trials of novel agents, both alone and in combination with traditional cytotoxic chemotherapy, have been completed or are nearing completion. It appears that the targeted agents may have the most efficacy in combination with cytotoxic chemotherapy or in a multi-targeted agent approach. Conclusions. Chemotherapy offers the opportunity for a meaningful response rate in women with endometrial cancer, but the responses are often short lived and cure is uncommon in the setting of recurrent disease. The recent increase in molecular targets has led to the availability of many novel therapies. Determining how these agents are to be used, alone or in combination with "standard" therapies, needs to be defined and translational Studies are needed to develop rational combinations of these novel agents before we can move into clinical trials. (C) 2009 Elsevier Inc. All rights reserved