Nuclear receptor 4A (NR4A) family - orphans no more

被引：138

作者：

Safe, Stephen ^{[1
]}

Jin, Un-Ho ^{[1
]}

Morpurgo, Benjamin ^{[2
]}

Abudayyeh, Ala ^{[3
]}

Singh, Mandip ^{[4
]}

Tjalkens, Ronald B. ^{[5
]}

机构：

[1] Texas A&M Univ, Coll Vet Med, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA

[2] Texas A&M Univ, Texas A&M Inst Genom Med, 670 Raymond Stotzer Pkwy, College Stn, TX 77843 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Gen Internal Med, Houston, TX 77030 USA

[4] Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Dept Pharmaceut, Tallahassee, FL 32307 USA

[5] Colorado State Univ, Dept Toxicol & Neurosci, 1680Campus Delivery, Ft Collins, CO 80523 USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2016年 / 157卷

关键词：

NR4A; Multiple functions; Nuclear receptors; Novel ligands; SMOOTH-MUSCLE-CELLS; SMALL HETERODIMER PARTNER; RETINOIC ACID RECEPTOR; ELEMENT-BINDING PROTEIN; VENTRAL TEGMENTAL AREA; NF-KAPPA-B; NGFI-B; GENE-EXPRESSION; TRANSCRIPTION FACTOR; GROWTH-FACTOR;

D O I：

10.1016/j.jsbmb.2015.04.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes induced by multiple stressors, and the NR4A receptors play an important role in maintaining cellular homeostasis and disease. There is increasing evidence for the role of these receptors in metabolic, cardiovascular and neurological functions and also in inflammation and inflammatory diseases and in immune functions and cancer. Despite the similarities of NR4A1, NR4A2 and NR4A3 and their interactions with common cis-genomic elements, they exhibit unique activities and cell-/tissue-specific functions. Although endogenous ligands for NR4A receptors have not been identified, there is increasing evidence that structurally-diverse synthetic molecules can directly interact with the ligand binding domain of NR4A1 and act as agonists or antagonists, and ligands for NR4A2 and NR4A3 have also been identified. Since NR4A receptors are key factors in multiple diseases, there are opportunities for the future development of NR4A ligands for clinical applications in treating multiple health problems including metabolic, neurologic and cardiovascular diseases, other inflammatory conditions, and cancer. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：48 / 60

页数：13

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