Childhood Cumulative Risk Exposure and Adult Amygdala Volume and Function

被引：47

作者：

Evans, Gary W. ^{[1
,2
]}

Swain, James E. ^{[3
,4
]}

King, Anthony P. ^{[3
]}

Wang, Xin ^{[3
]}

Javanbakht, Arash ^{[3
,5
]}

Ho, S. Shaun ^{[3
]}

Angstadt, Michael ^{[3
]}

Phan, K. Luan ^{[6
]}

Xie, Hong ^{[7
]}

Liberzon, Israel ^{[3
]}

机构：

[1] Cornell Univ, Dept Design & Environm Anal, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Human Dev, Ithaca, NY 14853 USA

[3] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[4] Yale Univ, Yale Child Study Ctr, New Haven, CT USA

[5] Wayne State Univ, Dept Psychiat & Neurosci, Detroit, MI USA

[6] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA

[7] Univ Toledo, Dept Neurosci, 2801 W Bancroft St, Toledo, OH 43606 USA

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2016年 / 94卷 / 06期

关键词：

children; cumulative risk; amygdala volume; amygdala function; POSTTRAUMATIC-STRESS-DISORDER; EARLY-LIFE STRESS; SOCIOECONOMIC-STATUS; COGNITIVE APPRAISAL; FACIAL EXPRESSIONS; HIPPOCAMPAL VOLUME; BRAIN; HEALTH; CHILDREN; SEGMENTATION;

D O I：

10.1002/jnr.23681

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Considerable work indicates that early cumulative risk exposure is aversive to human development, but very little research has examined the neurological underpinnings of these robust findings. This study investigates amygdala volume and reactivity to facial stimuli among adults (mean 23.7 years of age, n=54) as a function of cumulative risk exposure during childhood (9 and 13 years of age). In addition, we test to determine whether expected cumulative risk elevations in amygdala volume would mediate functional reactivity of the amygdala during socioemotional processing. Risks included substandard housing quality, noise, crowding, family turmoil, child separation from family, and violence. Total and left hemisphere adult amygdala volumes were positively related to cumulative risk exposure during childhood. The links between childhood cumulative risk exposure and elevated amygdala responses to emotionally neutral facial stimuli in adulthood were mediated by the corresponding amygdala volumes. Cumulative risk exposure in later adolescence (17 years of age), however, was unrelated to subsequent adult amygdala volume or function. Physical and socioemotional risk exposures early in life appear to alter amygdala development, rendering adults more reactive to ambiguous stimuli such as neutral faces. These stress-related differences in childhood amygdala development might contribute to the well-documented psychological distress as a function of early risk exposure. (c) 2015 Wiley Periodicals, Inc.

引用

页码：535 / 543

页数：9