Drug release behavior of poly (lactic-glycolic acid) grafting from sodium alginate (ALG-g-PLGA) prepared by direct polycondensation

被引：10

作者：

Shi, Gang ^{[1
]}

Ding, Yuanyuan ^{[1
]}

Zhang, Xin ^{[1
]}

Wu, Luyan ^{[1
]}

He, Fei ^{[1
]}

Ni, Caihua ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Food Colloids & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu Provinc, Peoples R China

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2015年 / 26卷 / 16期

关键词：

sodium alginate; hydrophobic modification; direct polycondensation; drug carrier; DELIVERY; NANOPARTICLES; DEGRADATION; HYDROGELS; CHITOSAN;

D O I：

10.1080/09205063.2015.1080456

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Hydrophobically modified sodium alginate, poly (lactic-glycolic acid) grafting from sodium alginate (ALG-g-PLGA), was successfully synthesized through direct one-step polymerization of sodium alginate, glycolic acid, and lactic acid. ALG-g-PLGA self-assembled to colloidal nanoparticles and subsequently hydrogel microspheres were obtained by crosslinking ALG-g-PLGA nanoparticles in the solution of calcium chloride. The modified hydrogel microspheres could be used as the drug delivery vehicles for a hydrophobic ibuprofen. Compared with sodium alginate, ALG-g-PLGA demonstrated an improved drug loading rate, encapsulation efficiency, and prolonged release speed. The products, as novel and highly promising biomaterials, have potential applications.

引用

收藏

页码：1152 / 1162

页数：11

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