Clinical translation of FLASH radiotherapy: Why and how?

被引：355

作者：

Bourhis, Jean ^{[1
,2
,3
]}

Montay-Gruel, Pierre ^{[1
,2
,3
]}

Jorge, Patrik Goncalves ^{[1
,2
,3
,4
]}

Bailat, Claude ^{[4
]}

Petit, Benoit ^{[1
,2
,3
]}

Ollivier, Jonathan ^{[1
,2
,3
]}

Jeanneret-Sozzi, Wendy ^{[1
,2
]}

Ozsahin, Mahmut ^{[1
,2
]}

Bochud, Francois ^{[4
]}

Moeckli, Raphael ^{[4
]}

Germond, Jean-Francois ^{[4
]}

Vozenin, Marie-Catherine ^{[1
,2
]}

机构：

[1] Lausanne Univ Hosp, Dept Oncol, Dept Radiat Oncol, Lausanne, Switzerland

[2] Lausanne Univ, Lausanne, Switzerland

[3] Lausanne Univ Hosp, Dept Oncol, Dept Radiat Oncol, Radiat Oncol Lab, Lausanne, Switzerland

[4] Lausanne Univ, Lausanne Univ Hosp, Inst Radiat Phys, Lausanne, Switzerland

来源：

RADIOTHERAPY AND ONCOLOGY | 2019年 / 139卷

基金：

瑞士国家科学基金会;

关键词：

FLASH-radiotherapy; Normal tissue protection; Differential effect; Clinical trial; ELECTRON-BEAM DOSIMETRY; ULTRAHIGH DOSE-RATES; OXYGEN; CELLS; SURVIVAL; IRRADIATION; RADIATION; PULSES; DELIVERY; CANCER;

D O I：

10.1016/j.radonc.2019.04.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the past decades, technological advances have transformed radiation therapy (RT) into a precise and powerful treatment for cancer patients. Nevertheless, the treatment of radiation-resistant tumors is still restricted by the dose-limiting normal tissue complications. In this context, FLASH-RT is emerging in the field. Consisting of delivering doses within an extremely short irradiation time, FLASH-RT has been identified as a promising new tool to enhance the differential effect between tumors and normal tissues. Indeed, preclinical studies on various animal models and a veterinarian clinical trial have recently shown that compared to conventional dose-rate RT, FLASH-RT could control tumors while minimizing normal tissue toxicity. In the present review, we summarize the main data supporting the clinical translation of FLASH-RT and explore its feasibility, the key irradiation parameters and the potential technologies needed for a successful clinical translation. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：11 / 17

页数：7

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